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PDK1 expressed in ovarian cancer cells promotes CD8+ T cell apoptosis through PD-L1. (a) Apoptosis rates of CD8+ T cells co-cultured with A2780CP cells with PDK1 knockdown or control cells. (b) Apoptosis rates of CD8+ T cells co-cultured with OVCAR3 cells overexpressing PDK1 or control cells in the presence of anti-PD-L1 or control IgG. Representative data from three experiments are shown (*P < .05 **P < .01).
