Figure 3:

Substantial loss of kidney function, ESKD or death from kidney disease. Substantial loss of kidney function was defined as doubling of serum creatinine level in the CREDENCE¹¹ and EMPA-REG OUTCOME⁸ trials and sustained 40% decline in estimated glomerular filtration rate in the CANVAS Program⁹ and DECLARE-TIMI 58 trial.¹⁰ The size of each box is weighted using the inverse variance method. Note: CI = confidence interval, ESKD = end-stage kidney disease, HR = hazard ratio, SGLT2 = sodium-glucose cotransporter-2.