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. 2019 Oct 2;8:e48482. doi: 10.7554/eLife.48482

Figure 2. Oncogenic KRAS alters footpad epidermis spindle orientation in a NuMA-dependent manner.

(A,B) Radial histogram of mitotic spindles in adult backskin 21 days after tamoxifen-induced recombination in control (A) and K5CreER; KRASG12D mice (B). (C,D) Radial histogram of mitotic spindles in adult footpad epidermis, 21 days after tamoxifen-induced recombination in control (C) and K5CreER; KRASG12D mice, (n = 78 cells), and (D) (n = 64 cells). (E) Radial histogram of mitotic spindles in adult footpad 21 days after tamoxifen-induced recombination in K5CreER; KRASG12D;NuMAΔMTBD mice (n = 57 cells). Note that the data in 2C is the same as that presented in Figure 1—figure supplement 2E.

Figure 2.

Figure 2—figure supplement 1. Radial histogram of cell division orientation in the footpad epidermis from NuMA mutant mice (K14-Cre;NuMAMTBD/MTBD).

Figure 2—figure supplement 1.

n = 41 cells.