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. 2019 Oct 16;6(5):ENEURO.0165-19.2019. doi: 10.1523/ENEURO.0165-19.2019

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Copyright © 2019 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — The mitigating effect of proBDNF on SD-induced deficits in acquisition of fear extinction required NR2B subunit of NMDA receptors. A, Treatment procedure. Conditioned rats received post-SD infusion(s) and then tested 48 h following contextual conditioning. B, The effect of proBDNF, mBDNF, and anti-proBDNF antibody on SD-induced extinction impairment; ***p < 0.001: SD or CON-Anti versus CON or SD-proBDNF; ##p < 0.01, ###p < 0.001: SD-mBDNF versus CON or SD-proBDNF; %%p < 0.01: SD-mBDNF versus SD or CON-Anti; n = 7 per group. C, Rats were subjected SD between ZT0 and ZT4, the effect of co-infusion NMDA receptor antigonists (CPP, NVP, and Ro25) and proBDNF on freezing levels were tested; ***p < 0.001: Sal-proBDNF versus Sal-Sal, CPP-proBDNF or Ro25-proBDNF; ##p < 0.01, ###p < 0.001: NVP-proBDNF versus Sal-Sal, CPP-proBDNF or Ro25-proBDNF; n = 8 per group. D, The proBDNF levels of SD rats that treated with proBDNF and mBDNF throughout the circadian cycle; ***p < 0.001: SD versus CON or SD-proBDNF; ##p < 0.01: SD-mBDNF versus CON or SD-proBDNF; %p < 0.05: SD-mBDNF versus SD; n = 6 per time point.