Whole brain ANOVAs for brain responses to food cues and post-hoc tests. A. There was a significant interaction effect (group × time) for brain responses to HC vs. LC food cues in the DLPFC. B. BS group showed significant reduction in brain responses to HC vs. LC food cues after surgery. There were significant group × time interaction effects for brain responses to HC food cues, and significant condition × time interaction effects for brain activations in the DLPFC in the BS group. C. Changes in DLPFC activation in response to HC vs. LC food cues were positively correlated with changes in ghrelin. D. Positive correlation between changes in craving for HC versus LC food cues and changes in DLPFC activation in response to HC vs. LC food cues following LSG surgery in the BS group.
Abbreviation: BS, bariatric surgery; Pre-BS, obese patients who received MRI scan before surgery; Post-BS, obese patients who received MRI scan at one month after surgery; CtrT, control subjects who received MRI scan at baseline; CtrRT, control subjects who received MRI scan one month after the first scan; DLPFC, dorsolateral prefrontal cortex; HC, high-calorie; LC, low calorie.