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. 2019 Oct 10;10(1):459–468. doi: 10.1080/21655979.2019.1676485

Figure 4.

Figure 4.

SREBP1 overexpressionincreases chemoresistance of HCT116 cells to Gem. a, HCT116 cells were transfected into Lv- SREBP1 or Lv-scramble for 48 h, SREBP1 and caspase-7 was detected by western blot assay. b, HCT116 cells were transfected into Lv- SREBP1 or Lv-scramble for 24 h, then treated with 20 uM Gem for 72 h. Cell proliferation assay ofHCT116 cells using cell counting kit-8 assay. c, HCT116 cells were transfected into Lv- SREBP1 or Lv-scramble for 24 h, then treated with 20 uM Gem for 72 h. Cell apoptosis was analyzed on a FACSCalibur. Data are shown as mean±SD.