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States of pluripotency. Embryonic stem cells transition through distinct states of pluripotency (naïve, formative) before they undergo lineage commitment (and then gastrulation). This transition is accompanied by various changes in chromatin, including gain of bivalent domains and global DNA methylation, global gain of H3K9 dimethylation (H3K9me2) and loss of chromatin accessibility. In addition, many genes are regulated by changing sets of enhancers.
