Abstract
Toxicological studies were performed in an AAALAC (American Association for Laboratory Animal Care)-approved laboratory at BASF SE, Ludwigshafen, Germany, in accordance with the German Animal Welfare Act and the effective European Council Directive 2010/63/EU. Data were recorded in the BASF SE pathology data capture system.
Historical control data (2008–2013) were compiled for
a) Twelve 28-day studies performed according to OECD 407 with mice from Janvier C57BL/j Rj (J) and Charles River CD-1 (CRL), in total 73 control females and 73 control males, 5–8 weeks old at the beginning of the studies. Data collected: terminal body weight, organ weights of adrenal glands, brain, epididymides, heart, kidneys, liver, ovaries, prostate, seminal vesicles (with coagulating glands), spleen, testes, thymus, uterus.
b) Eight immunotoxicity studies (duration of 28 days) performed according to EPA Health Effects Test Guidelines OPPTS 870.7800 with mice from Janvier C57BL/j Rj (J). 48 control females and 16 control males 5–7 weeks old at the beginning of the studies. Data collected: terminal body weight, mean absolute and relative weights of spleen and thymus.
This data helps interpreting effects caused by treatment in toxicology studies in the mouse.
Coefficients of variation were calculated and discussed in the accompanying research paper:
“Variance of body and organ weights in 28-day studies in mice” (Marxfeld et al. 2019).
Keywords: Organ weight, Mouse, Immune system, Toxicity, Endocrine system
Specifications Table
| Subject | Toxicology |
| Specific subject area | Organ weight measurement and interpretation in toxicological studies in the mouse |
| Type of data | Table |
| How data were acquired | Body and organ weights recorded and transferred to proprietary in-house data capture system Balances: Mettler Delta Range XS 603 S, PM 480, Toledo XS6002S, AE 160 |
| Data format | Raw |
| Parameters for data collection | Body and organ weights of mouse studies performed from 2008 to 2013 at BASF SE, Ludwigshafen, Germany |
| Description of data collection | Weighing of organs and carcass during routine necropsies performed according to OECD guideline 407 [1] and EPA Health Effects Test Guidelines OPPTS 870.7800 [2] |
| Data source location | Institution: BASF SE City/Town/Region: Ludwigshafen Country: Germany |
| Data accessibility | With the article |
| Related research article | [3] |
Value of the Data
|
1. Data
The dataset contains organ weights (both absolute and in relation to body weight) of mice with information about the mouse strain and age of animals. Data are provided in excel format containing the following data (Table in Supplementary data):
-
a)
Twelve 28-day studies performed according to OECD 407 with mice from Janvier C57BL/j Rj (J) and Charles River CD-1 (CRL), in total 73 control females and 73 control males, 5–8 weeks old at the beginning of the studies. Data collected: terminal body weight, organ weights of adrenal glands, brain, epididymides, heart, kidneys, liver, ovaries, prostate, seminal vesicles (with coagulating glands), spleen, testes, thymus, uterus.
-
b)
Eight immunotoxicity studies (duration of 28 days) performed according to EPA Health Effects Test Guidelines OPPTS 870.7800 with mice from Janvier C57BL/j Rj (J). 48 control females and 16 control males 5–7 weeks old at the beginning of the studies. Data collected: terminal body weight, mean absolute and relative weights of spleen and thymus.
| Supplier | Strain | Age at beginning of study | Abbreviation | Number of control mice/sex | Number of studies |
|---|---|---|---|---|---|
| Janvier | C57BL/j Rj | 5–7wks | j57 | 15 | 3 |
| Janvier | C57BL/j Rj | 7–8wks | j78 | 23 | 4 |
| CRL | CD-1 | 5–7wks | c57 | 30 | 4 |
| CRL | CD-1 | 7–8wks | c78 | 5 | 1 |
2. Experimental design, materials, and methods
Weighing of organs and carcass during routine necropsies performed according to OECD guideline 407 [1] and EPA Health Effects Test Guidelines OPPTS 870.7800 [2]. Body and organ weights recorded and transferred to proprietary in-house data capture system, balances used: Mettler Delta Range XS 603 S, PM 480, Toledo XS6002S, AE 160. No filtering or analyses was done on the data presented here.
Footnotes
Supplementary data to this article can be found online at https://doi.org/10.1016/j.dib.2019.104632.
Conflict of Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Appendix A. Supplementary data
The following is/are the supplementary data to this article:
References
- 1.OECD . 2008. Guidelines for Testing of Chemicals; Method No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents; Adopted 03 Oct 2008.https://www.oecd-ilibrary.org/environment/test-no-407-repeated-dose-28-day-oral-toxicity-study-in-rodents_9789264070684-en [Google Scholar]
- 2.EPA . 1998. U.S. EPA Health Effects Test Guidelines OPPTS 870.7800; Immunotoxicity (Aug 1998)https://www.regulations.gov/document?D=EPA-HQ-OPPT-2009-0156-0049 [Google Scholar]
- 3.Marxfeld H.A., Küttler K., Dammann M., Gröters S., van Ravenzwaay B. Variance of body and organ weights in 28-day studies in mice. Regul. Toxicol. Pharmacol. 2019 Sep 5:104472. doi: 10.1016/j.yrtph.2019.104472. [DOI] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.