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. 2006 May 23;20(3):109–112. doi: 10.1002/jcla.20110

Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto's thyroiditis in Chinese patients in Taiwan†

Wei‐Yong Lin 1,2, Lei Wan 2,3, Chang‐Hai Tsai 2,4, Rong‐Hsing Chen 5, Cheng‐Chun Lee 2, Fuu‐Jen Tsai 2,3,4,✉
PMCID: PMC6807492  PMID: 16721822

Abstract

The etiology of the autoimmune thyroid, Hashimoto's thyroiditis (HT) is not very clear. However, genetic susceptibility is thought to play a critical role. The vitamin D receptor (VDR)‐related endocrine system has been demonstrated to be able to carry out modulation of the immune response. Here, we investigated whether single nucleotide polymorphisms (SNPs) of VDR are associated with HT patients. VDR SNP was detected by polymerase chain reaction (PCR)‐based restriction analysis in 109 patients with HT and 90 normal controls. Significant differences were found in the genotype distribution of VDR SNP between Hashimoto's thyroiditis patients and controls (P=0.0458). Allelic frequency of the VDR gene distinguished HT patients from controls (P=0.0089). The results revealed a significant difference between HT patients and normal controls in VDR SNP and a statistic correlation between VDR‐FokI polymorphisms and HT formation. It could be concluded that patients who carry the C/C homozygote of the VDR‐FokI gene polymorphism in exon 2 may have a higher risk of developing HT in Chinese patients in Taiwan. J. Clin. Lab. Anal. 20:109–112, 2006. © 2006 Wiley‐Liss, Inc.

Keywords: Hashimoto's thyroiditis, single nucleotide polymorphisms (SNPs), vitamin D receptor, autoimmune thyroid

†

Wei‐Yong Lin and Lei Wan contributed equally to this work.

REFERENCES

  • 1. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489–499. [DOI] [PubMed] [Google Scholar]
  • 2. Vanderpump MP, Tunbridge WM. Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid 2002;12:839–847. [DOI] [PubMed] [Google Scholar]
  • 3. Vaidya B, Kendall‐Taylor P, Pearce SH. The genetics of autoimmune thyroid disease. J Clin Endocrinol Metab 2002;87:5385–5397. [DOI] [PubMed] [Google Scholar]
  • 4. Weetman AP. Cellular immune responses in autoimmune thyroid disease. Clin Endocrinol (Oxf) 2004;61:405–413. [DOI] [PubMed] [Google Scholar]
  • 5. Chistiakov DA. Immunogenetics of Hashimoto's thyroiditis. J Autoimmune Dis 2005;2:1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6. Ban Y, Taniyama M. Vitamin D receptor gene polymorphism is associated with Graves' disease in the Japanese population. J Clin Endocrinol Metab 2000;85:4639–4643. [DOI] [PubMed] [Google Scholar]
  • 7. Ban Y, Taniyama M, Katagiri T. Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease. Thyroid 2000;10:475–480. [DOI] [PubMed] [Google Scholar]
  • 8. Ban Y, Taniyama M. Vitamin D receptor gene polymorphisms in Hashimoto's thyroiditis. Thyroid 2001;11:607–608. [DOI] [PubMed] [Google Scholar]
  • 9. Oakley‐Girvan I, Feldman D, Eccleshall TR, et al. Risk of early‐onset prostate cancer in relation to germ line polymorphisms of the vitamin D receptor. Cancer Epidemiol Biomarkers Prev 2004;13:1325–1330. [PubMed] [Google Scholar]
  • 10. Kawakami‐Tani T, Fukawa E, Tanaka H, Abe Y, Makino I. Effect of 1 alpha‐hydroxyvitamin D3 on serum levels of thyroid hormones in hyperthyroid patients with untreated Graves' disease. Metabolism 1997;46:1184–1188. [DOI] [PubMed] [Google Scholar]
  • 11. Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. 1,25‐dihydroxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181–1183. [DOI] [PubMed] [Google Scholar]
  • 12. Adorini L. Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases. Int Immunopharmacol 2002;2:1017–1028. [DOI] [PubMed] [Google Scholar]
  • 13. Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J 2001;15:2579–2585. [DOI] [PubMed] [Google Scholar]
  • 14. Fournier C, Gepner P, Sadouk M, Charreire J. In vivo beneficial effects of cyclosporin A and 1,25‐dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990;54:53–63. [DOI] [PubMed] [Google Scholar]
  • 15. Collins JE, Heward JM, Nithiyananthan R, et al. Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians. Clin Endocrinol (Oxf) 2004;60:618–624. [DOI] [PubMed] [Google Scholar]
  • 16. Loder N. Genetic variations can point the way to disease genes. Nature 1999;401:734. [DOI] [PubMed] [Google Scholar]
  • 17. Tomer Y, Davies TF. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 2003;24:694–717. [DOI] [PubMed] [Google Scholar]
  • 18. Ayadi H, Hadj Kacem H, Rebai A, Farid NR. The genetics of autoimmune thyroid disease. Trends Endocrinol Metab 2004;15:234–239. [DOI] [PubMed] [Google Scholar]
  • 19. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004;338:143–156. [DOI] [PubMed] [Google Scholar]

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