Abstract
The floral variant of follicular lymphoma (FL‐F) is an unusual variant of follicular lymphoma. The malignant “follicles” have an unusual “floral” appearance due to the proliferation of surrounding and infiltrating small lymphocytes. This variant of malignant lymphoma has been supported by immunohistochemical immunophenotyping and gene‐rearrangement studies; however, the flow cytometric findings have not previously been described. We report the flow cytometric findings in two cases of FL‐F. The surrounding and infiltrating small lymphocytes represented mantle cells which, in one case, obscured monoclonality were CD10+, supporting a follicular center cell origin. J. Clin. Lab. Anal. 12:310–314, 1998. © 1998 Wiley‐Liss, Inc.
Keywords: flow cytometry, follicular lymphoma, floral variant
References
- 1. Goates JJ, Kamel OW, LeBrun DP, Benharroch D, Dorfman RF: Floral variant of follicular lymphoma: Immunological and molecular studies support a neoplastic process. Am J Surg Path 18 (1): 37–47, 1994. [DOI] [PubMed] [Google Scholar]
- 2. Osborne BM, Butler JJ: Follicular lymphoma mimicking progressive transformation of germinal centers. Am J Clin Pathol 88: 264–269, 1987. [DOI] [PubMed] [Google Scholar]
- 3. Sandhaus LM, Voelkerding K, Raska KJ: Follicular lymphoma mimicking progressive transformation of germinal centers: Immunologic analysis of a case [letter]. Am J Clin Pathol 90: 518–519, 1988. [DOI] [PubMed] [Google Scholar]