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. 2005 Nov 21;19(6):276–281. doi: 10.1002/jcla.20090

Association of the −183 polymorphism in the IFN‐γ gene promoter with hepatitis B virus infection in the Chinese population

Suxia Qi 1,2,†, Bangwei Cao 3,4,‡, Mingwei Jiang 4, Changqing Xu 2, Yue Dai 3, Kun Li 2, Kun Wang 1,2, Yang Ke 5, Tao Ning 5,✉
PMCID: PMC6807984  PMID: 16302211

Abstract

Interferon‐γ (IFN‐γ) is a pleiotropic cytokine that plays an important role in regulating cellular immune responses. Regulation of IFN‐γ expression is considered to be strictly controlled at the transcriptional level. Two single‐nucleotide polymorphisms (SNPs) within the human IFN‐γ promoter (at positions −183 and −155) are considered to influence the promoter activity by altering the acting transcription factor‐1 (AP‐1) binding. We sought to assess the association between the SNPs of the IFN‐γ promoter and the host susceptibility to hepatitis B virus (HBV) infection, as well as its interaction with age and gender. No polymorphism at position−155 was detected in any of the participants, but a significant difference was found in the polymorphism at position –183 between the cases and controls (G/T and T/T vs. GG; P<0.01, odds ratio (OR)=4.50 (95% confidence interval (CI)=2.23–9.09). A susceptibility analysis revealed a gradually increased trend of the OR value from the young to the old group (OR=3.03, 4.17, and 5.56). Similarly, the association of the −183 polymorphism was markedly different in females (OR=5.71). Our data suggest that the polymorphism at position –183 of the IFN‐γ gene promoter may be associated with susceptibility to HBV infection, and age and gender factors are coordinative risk factors. J. Clin. Lab. Anal. 19:276–281, 2005. © 2005 Wiley‐Liss, Inc.

Keywords: hepatitis B virus, IFN‐γ, promoter, polymorphism, susceptibility

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