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. 2019 Sep 21;9(23):7016–7032. doi: 10.7150/thno.37601

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Lap/Hep@FGF4 reduces fibrotic scar tissue formation at the injury site and suppresses astrocyte migration in vitro. (A, B) Immunofluorescence staining and quantification data of laminin (green) and GFAP (red) in the spinal cord at 28 days post-injury. (C-F) Protein expression and quantification data of laminin, NG-2 and neurocan in each group. (G) Photograph of astrocyte migration regulated by Lap/Hep@FGF4 treatments at 5 days. (H) Quantification data of wound areas showed that astrocytes migrated evidently slower in the Lap/Hep@FGF4 group; # P < 0.05 versus the control group, $ P < 0.05 versus the control group, & P < 0.05 versus the free FGF4 treated group. All experiments were performed in triplicate and values were expressed as the Mean ± SD, n= 4 per group.