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. 2019 Sep 21;9(23):6856–6866. doi: 10.7150/thno.37794

Figure 5.

Figure 5

Mutational signatures in pre- or post-CRT rectal cancer. (A) Stacked bar graph displays the percentages of 6 possible substitutions for single nucleotide variations in pre-CRT (left) and post-CRT (right) tumors. ***, P<0.001. Three and two de novo signatures are identified in (B) pre-CRT and (C) post-CRT tumors, respectively. Signature RC Post-2 may be associated with CRT resistance.