Figure 4.

Structural changes during PHP. (a) Confocal images of immunostainings against the presynaptic protein Bruchpilot (BRP) and Cacophony (Cac) of representative NMJs transgenically overexpressing Cac‐GFP (elav^c155‐Gal4 > UAS‐cac‐GFP) in wild type (WT) and GluRIIA^SP16 mutants (GluRIIA^SP16). Note the increased BRP and Cacophony fluorescence intensity in GluRIIA^SP16 mutants (red data in cumulative frequency plots). Reprinted and adapted from (Li, Goel, Wondolowski, et al., 2018) with permission from Elsevier. (b) Cartoon summarizing structural changes during PHP. GluR (blue) perturbation increases Ca²⁺ channel levels (red) and Brp abundance (green). Further structural changes during PHP are summarized in the section “Active zone structure”