Table 1.
Parameter | WT | WT + Bay11–7082 | Dsg2mut/mut | Dsg2mut/mut + Bay11–7082 |
---|---|---|---|---|
Morphometry | ||||
n | 10 | 5 | 9 | 17 |
RWT (mm) | 0.63 ± 0.02 | 0.67 ± 0.08 | 0.55 ± 0.04 | 0.64 ± 0.02 |
LVM (mg) | 81.9 ± 4.9 | 87.9 ± 12.1 | 96.3 ± 6.03 | 92.9 ± 3.08 |
HW/BW (mg/g) | 4.6 ± 0.2 | 4.8 ± 0.2 | 5.0 ± 0.2 | 4.7 ± 0.1 |
Echocardiography | ||||
n | 10 | 5 | 9 | 17 |
FS (%) | 54.0 ± 1.5 | 53.1 ± 4.3 | 32.9 ± 3.4*†‡ | 49.5 ± 1.9 |
IVSd (mm) | 0.88 ± 0.03‡ | 1.07 ± 0.2 | 0.91 ± 0.04‡ | 0.95 ± 0.02‡ |
LVIDd (mm) | 2.87 ± 0.07 | 2.73 ± 0.26 | 3.22 ± 0.17 | 2.96 ± 0.06 |
LVIDs (mm) | 1.32 ± 0.05 | 1.28 ± 0.18 | 2.16 ± 0.16*†‡ | 1.50 ± 0.08 |
Electrocardiography | ||||
n | 10 | 5 | 9 | 17 |
Heart Rate (bpm) | 498 ± 12 | 464 ± 17† | 506 ± 12 | 512 ± 12 |
RR-I (ms) | 121 ± 2.8 | 130 ± 4.4† | 119 ± 2.7 | 118 ± 2.5 |
PR-I (ms) | 40.0 ± 0.9 | 44.1 ± 2.3 | 40.3 ± 1.6 | 39.0 ± 0.9 |
Pd (ms) | 11.7 ± 0.2 | 10.1 ± 0.6 | 10.3 ± 0.6 | 10.1 ± 0.5 |
QRSd (ms) | 12.5 ± 0.4 | 12.7 ± 0.7 | 13.8 ± 1.5† | 11.4 ± 0.4 |
P-Amp (mV) | 0.08 ± 0.01 | 0.07 ± 0.01 | 0.06 ± 0.01 | 0.06 ± 0.003* |
R-Amp (mV) | 0.84 ± 0.07 | 0.70 ± 0.03 | 0.55 ± 0.04* | 0.66 ± 0.04* |
Q-Amp (mV) | −0.03 ± 0.01 | −0.03 ± 0.004 | −0.11 ± 0.02*†‡ | −0.06 ± 0.01 |
S-Amp (mV) | −0.25 ± 0.04 | −0.16 ± 0.02 | −0.042 ± 0.05* | −0.09 ± 0.04* |
WT, wildtype; RWT, relative wall thickness; LVM, left ventricular mass; HW, heart weight; BW, body weight; FS, fractional shortening; IVSd, interventricular septum thickness at end-diastole; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; RR-I, R-R interval; PR-I, P-R interval; Pd, P-wave duration; QRSd, QRS-wave duration; P-Amp, P-wave amplitude; R-Amp, R-wave amplitude; Q-Amp, Q-wave amplitude; S-Amp, S-wave amplitude. Data are shown as mean ± SEM
P<0.05 for any cohort vs. vehicle-treated WT mice
P<0.05 for any cohort vs. Bay11–7082-treated Dsg2mut/mut mice
P<0.05 for any cohort vs. Bay11–7082-treated WT mice determined by one-way ANOVA with Tukey’s multiple comparisons test.