Table 1.

Quantitative morphometric, echocardiographic and electrocardiographic data

Parameter	WT	WT + Bay11–7082	Dsg2^mut/mut	Dsg2^mut/mut + Bay11–7082
Morphometry
n	10	5	9	17
RWT (mm)	0.63 ± 0.02	0.67 ± 0.08	0.55 ± 0.04	0.64 ± 0.02
LVM (mg)	81.9 ± 4.9	87.9 ± 12.1	96.3 ± 6.03	92.9 ± 3.08
HW/BW (mg/g)	4.6 ± 0.2	4.8 ± 0.2	5.0 ± 0.2	4.7 ± 0.1
Echocardiography
n	10	5	9	17
FS (%)	54.0 ± 1.5	53.1 ± 4.3	32.9 ± 3.4^*^†‡	49.5 ± 1.9
IVSd (mm)	0.88 ± 0.03^‡	1.07 ± 0.2	0.91 ± 0.04^‡	0.95 ± 0.02^‡
LVIDd (mm)	2.87 ± 0.07	2.73 ± 0.26	3.22 ± 0.17	2.96 ± 0.06
LVIDs (mm)	1.32 ± 0.05	1.28 ± 0.18	2.16 ± 0.16^*^†‡	1.50 ± 0.08
Electrocardiography
n	10	5	9	17
Heart Rate (bpm)	498 ± 12	464 ± 17^†	506 ± 12	512 ± 12
RR-I (ms)	121 ± 2.8	130 ± 4.4^†	119 ± 2.7	118 ± 2.5
PR-I (ms)	40.0 ± 0.9	44.1 ± 2.3	40.3 ± 1.6	39.0 ± 0.9
Pd (ms)	11.7 ± 0.2	10.1 ± 0.6	10.3 ± 0.6	10.1 ± 0.5
QRSd (ms)	12.5 ± 0.4	12.7 ± 0.7	13.8 ± 1.5^†	11.4 ± 0.4
P-Amp (mV)	0.08 ± 0.01	0.07 ± 0.01	0.06 ± 0.01	0.06 ± 0.003^*
R-Amp (mV)	0.84 ± 0.07	0.70 ± 0.03	0.55 ± 0.04^*	0.66 ± 0.04^*
Q-Amp (mV)	−0.03 ± 0.01	−0.03 ± 0.004	−0.11 ± 0.02^*^†‡	−0.06 ± 0.01
S-Amp (mV)	−0.25 ± 0.04	−0.16 ± 0.02	−0.042 ± 0.05^*	−0.09 ± 0.04^*

WT, wildtype; RWT, relative wall thickness; LVM, left ventricular mass; HW, heart weight; BW, body weight; FS, fractional shortening; IVSd, interventricular septum thickness at end-diastole; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; RR-I, R-R interval; PR-I, P-R interval; Pd, P-wave duration; QRSd, QRS-wave duration; P-Amp, P-wave amplitude; R-Amp, R-wave amplitude; Q-Amp, Q-wave amplitude; S-Amp, S-wave amplitude. Data are shown as mean ± SEM

P<0.05 for any cohort vs. vehicle-treated WT mice

^†

P<0.05 for any cohort vs. Bay11–7082-treated Dsg2^mut/mut mice

^‡

P<0.05 for any cohort vs. Bay11–7082-treated WT mice determined by one-way ANOVA with Tukey’s multiple comparisons test.