Skip to main content
Journal of Lasers in Medical Sciences logoLink to Journal of Lasers in Medical Sciences
. 2019 Jul 6;10(3):185–188. doi: 10.15171/jlms.2019.29

Laser Versus Pneumatic Lithotripsy With Semi-Rigid Ureteroscope; A Comparative Randomized Study

Seyed Mohammadreza Rabani 1,*, Seyedhossein Rabani 2, Najmeh Rashidi 2
PMCID: PMC6817797  PMID: 31749943

Abstract

Introduction: Ureteral stones are among the most common disorders in the urologic field. Miniaturization of endoscopic devices in urology and extracorporeal shock wave lithotripsy (ESWL) has revolutionized the management of ureteral stones. The aim of this study was to compare the efficacy and results of laser versus pneumatic lithotripsy (PL) with semi-rigid ureteroscope in a randomized prospective clinical trial in removing stones.

Methods: 117 adult patients underwent transurethral lithotripsy (TUL) in a single academic center and by a single surgeon. The patients were randomized in 2 groups: In group 1, 58 patients with ureteral stones underwent ureteroscopy and stone fragmentation was done by Ho: YAG laser lithotripsy (LL) and in group 2, 59 patients underwent PL (Swiss LithoClast) by using the same ureteroscope.

Results: Mean age was 41.77 years and 41.1years in group one and 2 respectively (P=0.79), there was no significant difference in male to female ratio and mean stone in both groups. The success rate for stone clearance was 79.31% and 77.96% in group 1 and 2 respectively (P=0.52). No difference between complications was seen in both groups, but the duration of operations was different (significantly lower in group 2).

Conclusion: In both techniques, acceptable results were achieved. We have found a significant statistical difference in duration of operation between our results (P=0.001) and similar studies, while this was shorter in the pneumatic group in our study, it was longer in other similar ones. This might be a result of more experience in working with PL in our center.

Keywords: Laser lithotripsy, Pneumatic lithotripsy, Ureteroscopy

Introduction

Ureteral stones are among the most common disorders in the urologic field. In Europe and North America, 5 to 10% of the population develop stone formation during their lives, while; higher frequency of stone formation has been reported from other parts of the world such as Asia.1 Transurethral lithotripsy (TUL) has traditionally been considered for the surgical treatment of ureteral stones.2 Miniaturization of endoscopic devices in urology and extracorporeal shock wave lithotripsy (ESWL) has revolutionized the management of ureteral stones. Lithotripsy techniques such as holmium: yttrium-aluminum-garnet (Ho: YAG) laser lithotripsy (LL) and pneumatic lithotripsy (PL) have been introduced as the newest treatment methods, improving the success rate while decreasing complications. Ho: YAG laser is a modality used for the treatment of urinary and biliary stones which can work with frequencies of up to 50 Hz and can be used with very fine fibers of up to 200 microns.3 Recently, there has been an increase in the use of the Ho: YAG laser for TUL due to its fewer complications and lower incidence of stone upward migration.4 Although there are many studies that have compared the viability of these 2 methods, there are still many controversies about the results in these comparisons. The aim of this study was to compare the efficacy and results of laser versus PL with semi rigid ureteroscope among samples of Iranian population in a randomized prospective clinical trial.

Methods

The comparative clinical trial study was conducted in the urology department of Yasuj University of Medical Sciences between February 2015 and September 2016. During a prospective randomized clinical trial, 117 eligible patients underwent TUL. They were categorized in 2 groups using pseudorandomization: in group1, 58 patients with ureteral stones underwent ureteroscopy and stone fragmentation was done by Ho: YAG LL which operates at the wavelength of 2100 nm and in group two, 59 patients underwent PL by using the same ureteroscope. Semi-rigid ureteroscope (Wolf Germany) was used for stone access in all of the patients. Patients were placed in lithotomy position and lithotripsy was done by semi-rigid ureteroscope Wolf 8-9.8 F and Holmium laser (Auriga) by standard methods. Negative urine cultures were essential in every patient preoperatively. Exclusion criteria were: uncorrected coagulopathy, pregnancy, deformity, and inability to have lithotomy position and inability to access the stone during Ureteroscopy (URS).

After informing patients about the benefits and risks of procedures, written consents were obtained from them. Data analysis was performed using SPSS version 22 by analyzing with the t test. All of the procedures were done by the same urologist and in the same center.

Results

Mean age was 41.77 (±13.2) years and 41.1 (±12.8) years in group 1 and 2 respectively (P = 0.79). As shown in Table 1, there was no significant difference in male to female ratio in both groups (62% male in group 1 vs 67% male in group 2, p-value: 0.56). The success rate for stone clearance was 79.31% and 77.96% in group 1 and 2 respectively (P = 0.52).

Table 1. Demographic and Clinical Characteristics of Patients .

Group Laser (58) Pneumatic (59) P Value
Mean age ± SD, y 41.77 (± 13.2) 41.1(±12.8) 0.79
Male, n (%) 36 (62%) 40 (67%) 0.456

Table 2 showed preoperative stone data in patients in both groups. Various characteristics of ureteral stone were compared in both groups including stones’ size, laterality, location, quantities, diameter and duration of stone compactions. These stone’s characteristics achieve no significant difference in both groups (all P values were more than 0.05).

Table 2. Preoperative Stone Data in Patients in Both Groups .

Group Laser (58) Pneumatic (59) P Value
Mean stones size (mm) 9.29(± 4.1) 9.77(± 4.7) 0.45
Stone laterality
Right side
Left side

24
34

26
33
0.41
Stone location
Proximal
Middle
Distal

14
6
38

16
5
38
0.91
Stone numbers
One
Two
More than two

51
3
4

54
4
1
0.86
Stone diameter
<7 mm
7-10 mm
> 10mm

7
43
8

7
42
10
0.50
Duration of stone impaction
<7 days
7-21 days
>21 days

14
42
2

13
43
3
0.88

Patients’ intra- and postoperative data were seen in Table 3. No significant morbidity and no mortalities were encountered in patients of both groups. The significant difference was observed between the mean operation time of 2 groups (36.4 [± 10.25] minutes in group 1 vs 25.47 (±8.55) minutes in group 2, P value was <0.001). Mean hospital stay was the same in both groups (1.2 days). No significant differences were seen in intra- and postoperative complications between 2 groups.

Table 3. Patients’ Intraoperative and Postoperative Data .

Group Laser (58) Pneumatic (59) P Value
Mean operation time (min) 34.6 (± 10.25) 25.47(±8.55) <0.001
Complications
Mucosal damage 1 2 0.4
Residual or escaped stones 10 10 0.7
Mean hospital stay (day) 0.68
Out patient 20 22
One 28 28
More than one 10 9

Discussion

Ureteral stones are among the most common disorders in the urologic field which necessitate the therapeutic procedures. There are many alternatives for the treatment of ureteral stones when there is an indication for surgical intervention. ESWL, TUL, percutaneous antegrade URS, laparoscopy, and open surgery are available techniques at the present time. Improvement in intracorporeal and extracorporeal lithotripsy technologies mostly lead to successfully access and treat virtually any stones within the ureter.

According to some studies, PL used for TUL requires a wider straight working channel, and upward migration of the stones is a major drawback, especially for upper ureteral calculi5; therefore, it can be used only within a rigid probe. There is no electricity and little heat energy is produced which cause no adverse thermal damage to ureteral mucosal layer.6

Dolowy et al in their study concluded that this therapeutic technique was a versatile tool in all field of urology. Due to its viability, by reducing its cost, laser equipment will become a mandatory and indispensable asset in all urology wards.7 Fallah Karkan et al in their study about the clinical potency of the Ho: YAG laser on ureteral stones, based on its fiber caliber, concluded that all 3 types of laser caliber (200 Mm, 365 Mm, and 500 Mm fibers) had great efficacy in stone fragmentation, however; by increasing the laser caliber, the stone-free rate would significantly increase.8

By working with the photo-thermal mechanism, Ho: YAG laser can fragment stones into the crater and small pieces, thus; the risk of upward migration of stone fragments through the lumen could be lowered.9 Despite encountering this complication in our procedures, no significant statistical outcome was seen between the 2 groups.

Khoder et al revealed that Ho: YAG laser was an adequate tool for fragmenting the ureteral stones independent of their locations. Additionally, they suggested a combination of the semi-rigid and flexible ureteroscope could likely improve the stone-free rates for proximal stones regardless of their sizes.10 Jhanwar et al conducted another study by analyzing the outcomes of Ho: YAG LL and PL in children and concluded that both techniques were equally efficacious; however, holmium laser required more expertise and was a costly alternative and comparatively more advantageous in impacted calculus.11

Maghsoudi et al showed that Ho: YAG laser had more advantages over PL due to a higher efficacy of stone-free rate and a lower rate of upward displacement of ureteral stones, while their complications were the same and very rare.12 Razzaghi et al conducted a review of the literature on laser application in Iran and revealed that this technology has not yet found its position in Iran, especially in the field of urology, it might be due to problems in accessibility of laser devices and inadequacy of knowledge about this technology.13

In our study, the duration of operation among PL group was shorter and the cost was less than Ho: YAG LL group, which may be a result of more experience in working with PL in our center. However, Li et al, in a prospective randomized control trial, declared that Ho: YAG LL group showed significant benefits compared with the PL group in terms of mean operative time (about 15 minutes shorter with P = 0.001). on the other hand, they showed that Ho: YAG LL group seems to have to face the increased risks of postoperative stricture (24 postoperative cases in LL group versus 5 postoperative cases in PL group, P = 0.02).14 Several studies approved these findings as well.15,16

In contrast to previous ones, in a study done in China, no significant difference was found between the operation time for the 2 groups (55.9 ± 16.5 minutes in Ho: YAG LL group versus 62.4 ± 17.6 minutes in PL one).17 In a survey conducted among 349 patients, Jou et al found that using Ho: YAG could be time-consuming to disintegrate a very large stone.18 Thus, it may be essential to use it with other powerful and appropriate intracorporeal lithotripter in patients with very huge ureteral stones.

Akdeniz et al compared the efficacies of both methods and concluded that no differences were seen between operative time and stone-free rate, except hospitalization period in both groups (hospitalization period was shorter in LL group). They also mentioned that LL was more expensive than PL and these findings were in accordant to ours.19 In another study about the application of both of these technologies in renal and ureteral stones in pediatric age groups, Marcin et al concluded that Ho: YAG laser reduced the operation time and increased the efficacy of treatment, especially in renal calculi in comparison to LL.20

Yin et al in their meta-analysis found that Ho: YAG LL had significant superiority in comparison to PL in terms of early stone-free rate, delayed stone-free rate, shorter operative time and lower stone migration rate, but not yet in the postoperative hematuria rate and the ureteral perforation rate.4 They did not have any comparison between the costs of these procedures. On the other hand, their final sample sizes were not enough to have a definite consideration about their results.

Mostly, Ho: YAG LL group experienced fewer complications compared with the PL one. In a study conducted in Korea, Jeon et al observed that laser was better than PL in terms of stone-free rates as well complication rates.21 Related complications occurred in less than 1% in LL group and there was no evidence of renal deterioration after that. Bapat et al revealed that the complications and the need for auxiliary procedures were significantly less for Ho: YAG in comparison with PL.22 Recently Abedi et al declared that slightly higher stone-free rate was found in the LL group compared to PL group in treating ureteral stones.23 However, we found that there were no major complications between the 2 groups with no statistical significance.

Our study has some strength. All procedures were administered by one surgeon in one center which removed the technical bias in our results. Besides prospective nature of the study, recording the detailed information of patients and various characteristic of ureteral stones in patients helped to the comprehensiveness of our study. Some limitations of our study should be noticed too. Maybe more sample size would have a roll in the diversity of results compared to other studies. Our study was conducted among Iranian patients and maybe further studies with the population with different races would contribute to different results.

In conclusion, according to our results, by using both techniques, acceptable results were achieved. However, in the pneumatic group, the duration of operation was shorter and the cost was less than LL. There was no major complication with any statistically significant differences between the 2 groups.

Ethical Considerations

This study was confirmed in Yasuj University of medical sciences’ committee of research in biomedical sciences by the letter number: P/23/2/837:1397.06.11.

Conflict of Interests

The authors declare no conflict of interest.

Acknowledgments

The authors gratefully acknowledged the patients for their participation in this study.

Please cite this article as follows: Rabani SM, Rabani S, Rashidi N. Laser versus pneumatic lithotripsy with semi-rigid ureteroscope; a comparative randomized study. J Lasers Med Sci. 2019;10(3):185-188. doi:10.15171/jlms.2019.29.

References

  • 1.Tiselius HG. Stone incidence and prevention. Braz J Urol. 2000;26(5):452–462. [Google Scholar]
  • 2.Degirmenci T, Gunlusoy B, Kozacioglu Z. et al. Comparison of Ho:YAG laser and pneumatic lithotripsy in the treatment of impacted ureteral stones: an analysis of risk factors. Kaohsiung J Med Sci. 2014;30(3):153–158. doi: 10.1016/j.kjms.2013.08.007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Tipu SA, Malik HA, Mohhayuddin N. et al. Treatment of ureteric calculi--use of Holmium: YAG laser lithotripsy versus pneumatic lithoclast. J Pak Med Assoc. 2007;57(9):440–443. [PubMed] [Google Scholar]
  • 4.Yin X, Tang Z, Yu B. et al. Holmium: YAG laser lithotripsy versus pneumatic lithotripsy for treatment of distal ureteral calculi: a meta-analysis. J Endourol. 2013;27(4):408–414. doi: 10.1089/end.2012.0324. [DOI] [PubMed] [Google Scholar]
  • 5.Binbay M, Tepeler A, Singh A. et al. Evaluation of pneumatic versus holmium:YAG laser lithotripsy for impacted ureteral stones. Int Urol Nephrol. 2011;43(4):989–995. doi: 10.1007/s11255-011-9951-8. [DOI] [PubMed] [Google Scholar]
  • 6.Razzaghi MR, Razi A, Mazloomfard MM, Golmohammadi Taklimi A, Valipour R, Razzaghi Z. Safety and efficacy of pneumatic lithotripters versus holmium laser in management of ureteral calculi: a randomized clinical trial. Urol J. 2013;10(1):762–766. [PubMed] [Google Scholar]
  • 7.Dolowy L, Krajewski W, Dembowski J, Zdrojowy R, Kolodziej A. The role of lasers in modern urology. Cent European J Urol. 2015;68(2):175–182. doi: 10.5173/ceju.2015.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Fallah Karkan M, Ghiasy S, Ranjbar A, Javanmard B. Evaluation of 200 Mm, 365 Mm and 500 Mm Fibers of Ho:YAG Laser in Transurethral Lithotripsy of Ureteral: A Randomize Control Trial. J Lasers Med Sci. 2018;9(1):69–72. doi: 10.15171/jlms.2018.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Teichman JM, Vassar GJ, Bishoff JT, Bellman GC. Holmium:YAG lithotripsy yields smaller fragments than lithoclast, pulsed dye laser or electrohydraulic lithotripsy. J Urol. 1998;159(1):17–23. doi: 10.1016/s0022-5347(01)63998-3. [DOI] [PubMed] [Google Scholar]
  • 10.Khoder WY, Bader M, Sroka R, Stief C, Waidelich R. Efficacy and safety of Ho:YAG laser lithotripsy for ureteroscopic removal of proximal and distal ureteral calculi. BMC Urol. 2014;14:62. doi: 10.1186/1471-2490-14-62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Jhanwar A, Bansal A, Sankhwar S, Kumar M, Kanodia G, Prakash G. Outcome analysis of holmium laser and pneumatic lithotripsy in the endoscopic management of lower ureteric calculus in pediatric patients: a prospective study. Int Braz J Urol. 2016;42(6):1178–1182. doi: 10.1590/s1677-5538.ibju.2016.0211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Maghsoudi R, Amjadi M, Norizadeh D, Hassanzadeh H. Treatment of ureteral stones: A prospective randomized controlled trial on comparison of Ho:YAG laser and pneumatic lithotripsy. Indian J Urol. 2008;24(3):352–354. doi: 10.4103/0970-1591.39549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Razzaghi MR, Fallah Karkan M, Ghiasy S, Javanmard B. Laser Application in Iran Urology: A Narrative Review. J Lasers Med Sci. 2018;9(1):1–6. doi: 10.15171/jlms.2018.01. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Li L, Pan Y, Weng Z, Bao W, Yu Z, Wang F. A Prospective Randomized Trial Comparing Pneumatic Lithotripsy and Holmium Laser for Management of Middle and Distal Ureteral Calculi. J Endourol. 2015;29(8):883–887. doi: 10.1089/end.2014.0856. [DOI] [PubMed] [Google Scholar]
  • 15.Kitano H, Shinmei S, Goriki A, Iwamoto H, Hayashi T, Mutaguchi K. [Comparison of pneumatic lithotripter and Holmium YAG laser in transureteral lithotripsy (TUL)] Nihon Hinyokika Gakkai Zasshi. 2013;104(3):513–520. doi: 10.5980/jpnjurol.104.513. [DOI] [PubMed] [Google Scholar]
  • 16.Jou YC, Shen CH, Cheng MC, Lin CT, Chen PC. High-power holmium:yttrium-aluminum-garnet laser for percutaneous treatment of large renal stones. Urology. 2007;69(1):22–25. doi: 10.1016/j.urology.2006.08.1114. [DOI] [PubMed] [Google Scholar]
  • 17.Liu C, Zhou H, Jia W, Hu H, Zhang H, Li L. The Efficacy of Percutaneous Nephrolithotomy Using Pneumatic Lithotripsy vs the Holmium Laser: a Randomized Study. Indian J Surg. 2017;79(4):294–298. doi: 10.1007/s12262-016-1473-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Jou YC, Shen JH, Cheng MC, Lin CT, Chen PC. Percutaneous nephrolithotomy with holmium: Yttrium-aluminum-garnet laser and fiber guider--report of 349 cases. Urology. 2005;65(3):454–458. doi: 10.1016/j.urology.2004.09.069. [DOI] [PubMed] [Google Scholar]
  • 19.Akdeniz E, Irkilata L, Demirel HC. et al. A comparison of efficacies of holmium YAG laser, and pneumatic lithotripsy in the endoscopic treatment of ureteral stones. Turk J Urol. 2014;40(3):138–143. doi: 10.5152/tud.2014.46548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Zyczkowski M, Bogacki R, Nowakowski K. et al. Application of Pneumatic Lithotripter and Holmium Laser in the Treatment of Ureteral Stones and Kidney Stones in Children. Biomed Res Int. 2017;2017:2505034. doi: 10.1155/2017/2505034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Jeon SS, Hyun JH, Lee KS. A comparison of holmium:YAG laser with Lithoclast lithotripsy in ureteral calculi fragmentation. Int J Urol. 2005;12(6):544–547. doi: 10.1111/j.1442-2042.2005.01087.x. [DOI] [PubMed] [Google Scholar]
  • 22.Bapat SS, Pai KV, Purnapatre SS, Yadav PB, Padye AS. Comparison of holmium laser and pneumatic lithotripsy in managing upper-ureteral stones. J Endourol. 2007;21(12):1425–1427. doi: 10.1089/end.2006.0350. [DOI] [PubMed] [Google Scholar]
  • 23.Abedi AR, Razzaghi MR, Allameh F, Aliakbari F, Ranjbar A, Fallah Karkan M. Pneumatic Lithotripsy Versus Laser Lithotripsy for Ureteral Stones. J Lasers Med Sci. 2018;9(4):233–236. doi: 10.15171/jlms.2018.42. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Lasers in Medical Sciences are provided here courtesy of Shahid Beheshti University of Medical Sciences

RESOURCES