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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Hepatology. 2019 May 23;70(5):1582–1599. doi: 10.1002/hep.30693

FIGURE 3. Expression of inflammasome components is increased in tumors enhanced by NAFLD.

FIGURE 3.

After 6 weeks of low-fat diet (LFD) or high-fat diet (HFD), mice had splenic injection of MC38 colorectal cancer (CRC) cells and continued on LFD or HFD for 2 additional weeks. (A) The mRNA expression of inflammasome components (IL-1β, caspase-1, ASC, NLRP3, NLRC4) in tumors was examined by quantitative real-time PCR. n=6, each group. Data are shown as mean ± SEM per group. (B,C) Western blot analyses for IL-1β and caspase-1. Representative images are shown. The quantifications were analyzed by Image J. n=5, each group. Data are shown as mean ± SEM per group.