Figure 1.

The FAE-induced lymphopenic effect. Whole blood from 47 treatment-naïve, 35 FAE and 16 GA treated multiple sclerosis (MS) patients was analysed by FACS. FAE treatment was associated with significantly reduced percentage of total CD3, CD4 and CD8 T cells [linear regression controlling for age, gender, race and disease duration; t(76) = −3.407, P = 0.00105; t(76) = −3.032, P = 0.00332; t(76) = −2.874, P = 0.00525, respectively]. GA was not associated with changes in these T cell populations. NS = not-significant (P > 0.05). The lines in the box plot represent the quartiles of the dataset and the whiskers show the rest of the distribution, except for ‘outliers’ that were determined by a function of the inter-quartile range based on the package seaborn in python.