Figure 7.

Dual-targeting efficient of the dual-functionalized dendrimer evaluated in vivo using glioma-bearing CB-17 SCID mice as model. (a) Dual-targeting effect detected by in vivo imaging system after accumulating for 6 h, 12 h, 24 h and 48 h. The glioma-bearing mice were administrated with Cy5.5-labeled dendrimers at a Cy5.5 dose of 2 mg/kg. (b) Glioma-targeting effect of the dual-targeting dendrimer through observing the accumulated Cy5.5-labeled dendrimer in the excised brains at 24 h after administrating. (c) Dual-targeting efficacy was evaluated by calculating the fluorescent intensity accumulated in the brain of the glioma-bearing mice by LiveImaging software.