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(a) Construction of the dual-targeting dendrimer-based drug carrier. Reagents and conditions: (i) H2O, room temperature (RT), 30 min; (ii) H2O, RT, 30 min; (iii) H2O, RT, Argon, 1 h; (iv) H2O, RT, Argon, 4 h; (v) stirring in dark place, 24 h. (b) Schematic illustration of glioma targeting therapy across the BBB using the dual-targeting drug delivery system.
