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. 2019 Sep 27;50(11):3004–3012. doi: 10.1161/STROKEAHA.119.026545

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© 2019 American Heart Association, Inc.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Effects of genetically lower factor XI (FXI) levels in high-risk subgroups in the UK Biobank. Hazard ratios (HR) of subgroup analyses of relevant risk factors for (A) ischemic stroke and (B) venous thromboembolism and the FXI genetic score. We observed no significant interactions between any risk factors and the FXI genetic score. C, Survival analysis of differences in ischemic stroke rate for participants with the strongest observed genetic effect on FXI (red) and participants with no genetic effect (black) stratified by atrial fibrillation (AF) presence. While we observed similar relative risk reduction conferred by genetically lower FXI in the presence (dashed) and absence (solid) of AF, it can be seen that the absolute risk reduction in the AF subgroup is markedly higher.