Erratum to: Osteoporos Int
DOI: 10.1007/s00198-015-3386-5
Dear Editor,
In response to the communication from Drs. Bolland, Avenell, Grey, and Reid [1], we offer the following additional data and analyses. We apologize for several errors in Table 1 of the original publication [2]; the updated table is reproduced here (Table 1). We also offer the following method clarifications:
If studies reported multiple results, we used the data from participants who completed the studies (ie, per-protocol analysis).
Porthouse et al. stated: “In our unadjusted analysis we present the incidence of fracture by equally or unequally allocated groups as in any meta-analysis these need to be entered as two separate studies.” Therefore we treated these data as two studies since there was no overlapping in study participants among groups.
RRs were calculated using the original numbers of events and non-events in each group.
Table 1.
Summary of meta-analysis results for calcium plus vitamin D supplementation versus placebo and fracture risk
| Study | Status | Subgroup | Vitamin D (IU/day) | Calcium (mg/day) | Number of total fracture events/total | Number of hip fracture events/total | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reported RR/HR (95 % CI) | Calculated RR (95 % CI) | Treatment | Control | Reported RR/HR (95 % CI) | Calculated RR (95 % CI) | Treatment | Control | |||||
| Chapuy et al, 1992 [3] | Institutionalized | 800 | 1200 | ND |
0.69 (0.51, 0.93) |
66/877 | 97/888 | ND |
0.57 (0.34, 0.97) |
21/877 | 37/888 | |
| Chapuy et al, 2002 [4] | Institutionalized | 800 | 1200 | ND | ND | ND | ND |
Placebo vs. treatment 1.69 (0.96–3) |
0.62 (0.36, 1.07) |
27/393 | 21/190 | |
| Dawson-Hughes et al, 1997 [5] | Community-dwelling | 700 | 500 |
0.4 (0.2, 1.0) |
0.37 (0.19, 0.72) |
11/170 | 26/148 | ND |
0.29 (0.01, 7.08) |
0/170 | 1/148 | |
| Porthouse et al, 2005 [6] | Community-dwelling | Unequally allocated group | 800 | 1000 | ND |
0.96 (0.64, 1.43) |
34/714 | 69/1391 | ND |
0.39 (0.11, 1.34) |
3/714 | 15/1391 |
| Porthouse et al, 2005 [6] | Community-dwelling | Equally allocated group | 800 | 1000 | ND |
1.08 (0.61, 1.91) |
24/607 | 22/602 | ND |
2.48 (0.48, 12.78) |
5/607 | 2/602 |
| Prentice et al, 2013 [7]a | Community-dwelling | 400 | 1000 | ND |
0.92 (0.80, 1.04) |
405/7530b | 458/7801b | ND |
0.53 (0.31, 0.93) |
19/7530b | 35/7406b | |
| Salovaara et al, 2010 [8] | Community-dwelling | 800 | 1000 |
Adjusted HR 0.83 (0.61, 1.12) |
0.84 (0.63, 1.13) |
78/1586 | 94/1609 |
Adjusted HR 2.23 (0.41–12.29) |
2.03 (0.37, 11.06) |
4/1586 | 2/1609 | |
| Grant et al, 2015 [9]c | Community-dwelling with history of fracture | 800 | 1000 | ND |
0.95 (0.79, 1.15) |
179/1306 | 192/1332 | ND | ND | ND | ND | |
| Harwood et al, 2004 [10] | Community-dwelling with history of fracture | 800 | 1000 | ND |
0.72 (0.19, 2.78) |
3/29 | 5/35 | ND | ND | ND | ND | |
| Total (random model) |
0.86 (0.75, 0.98) |
800/12819 | 963/13806 |
0.61 (0.46, 0.82) |
79/11877 | 113/12234 | ||||||
CI confidence interval, ND no data, RR relative risk, HR hazard ratio, WHI Women’s Health Initiative
aData analyzing the WHI for adherence to assigned pills and no personal use of supplements from Table 6 in Prentice et al. [7]
bData provided from WHI investigators
cThe results from data of fracture confirmed by radiography
After incorporating the above suggestions from Bolland et al., the overall RR (95 % CI) for total fractures changed from 0.85 (0.73–0.98) to 0.86 (0.75–0.98) (Fig. 1), and the overall RR (95 % CI) for hip fractures changed from 0.70 (0.56–0.87) to 0.61 (0.46–0.82) (Fig. 2). These alterations do not affect the original publication’s conclusions. These data could further suggest that calcium with vitamin D supplementation may have a greater impact on preventing hip fractures than originally described.
Fig. 1.
Total fractures
Fig. 2.
Hip fractures
We also apologize for a typographical error in the original text [2]. The dataset contains 192 hip fractures, as listed in the original publication’s table (not 195). Since the number of 192 hip fractures were used in the data analysis, this error did not affect the outcome of the study.
Acknowledgments
The authors would like to thank Dr. Mei Chung and Zhuxuan Fu for their help in running the additional meta-analyses provided here.
Funding
Funding sources for the original analyses (DOI: 10.1007/s00198-015-3386-5) were declared in the publication. The authors have not received additional funding or compensation for the new work reported here.
Compliance with ethical standards
Conflicts of interest
The authors declared all conflicts of interest in the original publication (DOI: 10.1007/s00198-015-3386-5).
Footnotes
The online version of the original article can be found at 10.1007/s00198-015-3386-5.
Contributor Information
C. M. Weaver, Email: weavercm@purdue.edu
B. Dawson-Hughes, Email: bess.dawson-hughes@tufts.edu
J. M. Lappe, Email: joanlappe@creighton.edu
T. C. Wallace, Phone: 270.839.1776, FAX: 703.414.3742, Email: taylor.wallace@me.com
References
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