Table 1.
TGFβ and BMP ligands and related receptors.
| Ligand | Type 1 Receptor | Type 2 Receptor | Coreceptor | Intracellular Mediator | Ref. |
|---|---|---|---|---|---|
| TGFβ1/2/3 | ALK5 | TβRII | endoglin | SMAD2/3 | [9] |
| TGFβ1/2/3 | ALK5 | TβRII | betaglycan | SMAD2/3 | [10] |
| TGFβ1/2/3 | ALK1 | TβRII | endoglin | SMAD1/5/8 | [10] |
| TGFβ1/2/3 | ALK1/2 | ACVR2A, BMPR2 | SMAD2/3, SMAD1/5/8 | [10] | |
| BMP1 | BMPR1A | [11] | |||
| BMP2 | ALK2/3 | BMPR2, ACVR2A, ACVR2B | SMAD1/5/8, p38 | [12,13] | |
| BMP2 | ALK3 | BMPR2, ACVR2A, ACVR2B | SMAD2/3 | [14] | |
| BMP2 | ALK2/3 | BMPR2, ACVR2A | SMAD1/5/8 | [15] | |
| BMP4 | ALK1/2 | BMPR2 | SMAD1/5 | [16] | |
| BMP4 | ALK3 | BMPR2 | SMAD1/5, p38/ERK | [16] | |
| BMP9/10 | ALK1 | BMPR2, ACVR2A, ACVR2B | endoglin | SMAD1/5/8 | [17,18] |
| BMP6/7 | BMPRI | ACVR2A, BMPR2 | SMAD1/5/8, PI3K | [19] | |
| BMP6/7 | BMPRI | BMPRII | SMAD1/5/8 | [20] | |
| BMP6/7/9 | ALK2 | ACVR2A, ACVR2B | SMAD1/5 | [21] | |
| BMP2/6 | Alk2 | ACVR2A | SMAD1/5/8 | [22] |