Figure 6.

A four-week period was not sufficient to provoke regression of fibrosis. (a) Schematic representation of the animal experiments. Fibrocytes were depleted in mice of the respective group via the administration of VCV during a four-week regeneration period. (b) The direct comparison of serum ALT levels of mice sacrificed during fibrogenesis (see Section 3.5) and after regeneration shows an ameliorated disease state four weeks after the last TAA-administration. FC depletion during regeneration did not alter ALT levels. Median is depicted, Mann-Whitney U test was applied. (c) The direct comparison of hepatic hydroxyproline content indicates that a resolution of fibrosis cannot be observed after a regeneration period as short as four weeks. FC depletion during regeneration did not influence hydroxyproline levels. Mean is depicted, an unpaired t-test (two-tailed) was applied.