Table 1.
CMA substrates with an established function in cancer.
| Symbol | Protein Full Name | Function | Deregulated in: | CMA Substrat Ref: |
|---|---|---|---|---|
| GAPDH | Glyceraldehyde 3-phosphate deshydrogenase | Carbohydrate Metabolism | Non hodgkin’s B lymphoma | [34] |
| HK-2 | Hexokinase-2 | Carbohydrate Metabolism | Ovarian cancer | [32] |
| PKM2 | Pyruvate Kinase M2 | Carbohydrate Metabolism | AML, Melanoma | [31] |
| TP53 | Tumor Protein P53 | Tumor suppressor protein | Most of cancers | [26] |
| Mutant TP53 | Mutant Tumor Protein P53 | Oncogene | Most of cancers | [37] |
| MDM2 | Mouse Double Minute 2 homolog | E3 ubiquitin Ligase | Glioma, ALL, Melanoma | |
| PUMA | P53 upregulated modulator of apoptosis | BH3-only Pro-Apoptotic protein | Breast, Colon cancers | [46] |
| AF1Q (MLLT11) | MLLT11 Transcription Factor 7 Cofactor | Oncogene | AML | [27] |
| c-Myc | MYC Proto-Oncogene, BHLH Transcription Factor | Oncogene | Most of cancers | [44] |
| IκΒ | NFKB Inhibitor Alpha | NF-κB Inhibitor | B-cell lymphoma | |
| CHK1 | Checkpoint Kinase 1 | Cell cycle arrest | Breast, Ovarian Cancers | |
| Vav1 | Vav Guanine Nucleotide Exchange Factor 1 | (GEFs) for Rho family GTPases | Pancreatic cancer | [30] |
| HIF-1α | hypoxia Inducible Factor 1 alpha | Transcriptional regulator of the adaptive response to hypoxia | Lymphoma, colorectal cancers | [39] |
| NCOR1 | Nuclear Receptor Corepressor 1 | Promotes histone deacetylation and the formation of repressive chromatin structures | NSCLC, Gastric cancer | [29] |
| PED | Phosphoprotein Enriched in diabetes | Facilitate glucose transport | Gastric cancer | [28] |
| EPS8 | Epidermal Growth Factor Receptor Pathway Substrate 8 | Signaling adaptapter | Pancreatic cancer | [35] |
| RND3 | Rho Family GTPase 3 | Negative regulator of cytoskeletal organization | Gastric cancer | [36] |
| ANXs | Annexins | membrane scaffold, linking Ca2+ signalling to membrane dynamics | Breast Cancer | |
| TFEB | Transcription Factor EB | Transcription factor of lysosomal genes | Pancreatic, Renal cancers | [45] |
| EGFR | Epidermal Growth Factor receptor | Receptor tyrosine kinase binding ligands of the EGF family | Head and neck squamous cell carcinoma (HNSCC) | |
| GAL3 | Galectine-3 | Numerous cellular function: cell growth, adhesion, mitosis, proliferation and apoptosis | Diffuse large B-cell lymphoma (DLBCL), Prostate, liver cancer | |
| RKIP | Raf Kinase Inhibitor Protein | Raf Kinase Inhibitor | Prostate cancer | |
| UBQLN1 | Ubiquilin 1 | Ubiquitin like protein | Gastric cancer | |
| Bcl2-L10 | Bcl2 Like 10 | Anti-apoptotic protein of BCL2 family members | MM, MDS and AML | [47] |