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Model for loading double hexamer MCM at an origin of replication and the two pathways (i or ii) for encircling the 5’-3’ or 3’-5’ strands placing the CTD at the duplex (C@duplex). Translocation from (i) would proceed C-first separating hexamers, while translocation from (ii) would proceed N-first bypassing each hexamer. The shaded (grey) box identifies the conformations and states consistent in this report.
