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. 2019 Sep 25;9(24):7370–7383. doi: 10.7150/thno.37750

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(A) The threshold of tumor perfusion enhancement at various O₂-MBs doses was evaluated to determine the VN inducible dose of O₂-MBs. The legend of w/o means without O₂-MBs injection. (B) Linear correlation between perfusion intensity ratio and O₂-MBs dose. The correlation coefficients are 0.659, 0.795, and 0.719 at day 2, 4, and 6 after O₂-MBs treatment, respectively. Data are presented as mean ± standard deviation. (C) The transient effect of perfusion enhancement by MBs cavitation. Data are presented as box-and-whiskers plots and analyzed by one-way ANOVA (* p<0.05; † p<0.01). Each dot represents a sample (N=5 to 8 mice per group).