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. 2019 Sep 25;9(24):7268–7281. doi: 10.7150/thno.33006

Figure 2.

Figure 2

Effect of Maf1 knockout on AB-induced hypertrophy. The experiments were all carried out in mice. (A) Western blots showing Maf1 and vinculin expression in mouse hearts. Vinculin was used as an internal control. (B) Images of whole hearts from Maf1 knockout mice at 4 weeks after sham or AB surgery. (C-D) The heart or lung/body weight ratios were determined and showed that knockout of Maf1 could exacerbate AB-induced hypertrophy and pulmonary edema; WT+Sham n=7; MKO+Sham n=7; WT+AB n=8; MKO+AB n=6. (G) The effect of Maf1 knockout on ANP mRNA expression was determined by q-PCR, and GAPDH was used as an internal control; n=4-8. (E-F) Images of H&E-stained heart sections from mice at 4 weeks after sham or AB surgery; n=3. (H-K) The effects of Maf1 knockout on echocardiographic parameters (EF, LVEDd, LVEDs and LVPWd). *p<0.05 versus the corresponding control group. **p<0.01 versus the corresponding control group. NS indicates no significant difference versus the corresponding control group.