Figure 7.
Anticancer vaccination using cancer cell membrane-coated nanoparticles (CCNPs). (A) The membrane derived from cancer cells, along with its associated tumor antigens, is coated onto CpG ODN-loaded nanoparticle cores to yield a nanoparticulate anticancer vaccine (CpG-CCNPs). Upon delivery to APCs, the vaccine formulation enables activation of T cells with multiple antitumor specificities. (B) The co-delivery of both tumor antigens and CpG together in CpG-CCNPs greatly protects against tumor growth and enhances survival. Adapted with permission from 220. Copyright 2017 Wiley-VCH.