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. 2019 Oct 14;24(20):3694. doi: 10.3390/molecules24203694

Table 3.

Representative non-covalent and non-regioselective (C-R-) DNA-protein conjugation methods.

C-R- (Non Covalent/Non-Regioselective Methods)
DNA Protein DNA-Protein Conjugate
Asp/Glu-selective GCP [48,49]
graphic file with name molecules-24-03694-i037.jpg graphic file with name molecules-24-03694-i038.jpg graphic file with name molecules-24-03694-i039.jpg
Lys/Arg-selective molecular tweezers+ [50,51]
graphic file with name molecules-24-03694-i040.jpg graphic file with name molecules-24-03694-i041.jpg graphic file with name molecules-24-03694-i042.jpg
cucurbit(8)uril-mediated dimerization [52,53]
graphic file with name molecules-24-03694-i043.jpg graphic file with name molecules-24-03694-i044.jpg graphic file with name molecules-24-03694-i045.jpg

Note: The application of these methods to the synthesis of DNA-protein conjugates is still largely unexplored and is matter of current investigation in our group. The references here reported therefore refer to original works that describe the interaction between the supramolecular ligand and the POI.