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Effects of compounds 8a on inhibiting COL1A1 (A), ACTA2 (B), and TGFβ (C) mRNA levels in LX-2 cells after a 24-h treatment at the concentrations of 40, 80, 160 and 200 μM. The data were analyzed by the real-time PCR and presented as the mean ± SEM, (#) p < 0.05 as compared to that of the control group; (*) p < 0.05, (**) p < 0.01 as compared to that of TGF-β1 group. The mRNA expression levels were normalized against GAPDH.
