Skip to main content
. 2019 Sep 27;9(10):204. doi: 10.3390/metabo9100204

Figure 2.

Figure 2

Effects of perfusion with 10 mM (0–6 h) or 50 mM malonate (14–18 h) on interstitial levels of endogenous (12C) and 13C-labeled tricarboxylic acid cycle (TCA) metabolites succinate, fumarate, malate, isocitrate, alpha-ketoglutarate and related glutamine upon constant perfusion with 1 mM 13C4 succinate. Data are mean +/− SEM of 5 rats and expressed as % change of baseline abundance. The number of 13C or 12C atoms in the different metabolites after uptake of 13C4 succinate and one turn of the TCA cycle is indicated with the number of filled or open squares. Black bars under the x-axis illustrate time periods of malonate administration. * not detected.