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. 2019 Oct 5;11(10):515. doi: 10.3390/pharmaceutics11100515

Table 1.

Optimization of different effervescent ingredients.

Code Citric Acid (mg) Tartaric Acid (mg) Sodium Bicarbonate (mg) Effervescence Time (sec) pH
P1 84.0 166.0 250.0 54.00 ± 0.31 5.63 ± 0.23
P2 80.0 160.0 240.0 55.00 ± 0.46 5.61 ± 0.11
P3 74.0 146.0 220.0 46.00 ± 0.38 5.60 ± 0.21
P4 74.0 160.0 220.0 42.00 ± 0.21 5.67 ± 0.35
P5 40.0 80.0 120.0 51.00 ± 0.51 5.23 ± 0.24
P6 120.0 0.0 80.0 43.00 ± 0.53 4.48 ± 0.32
P7 120.0 0.0 90.0 45.00 ± 0.42 4.43 ± 0.21
P8 120.0 0.0 120.0 46.00 ± 0.34 4.53 ± 0.23
P9 0.0 120.0 120.0 30.00 ± 0.22 4.42 ± 0.43
P10 0.0 250.0 250.0 28.00 ± 0.37 4.27 ± 0.26
P11 84.0 84.0 250.0 54.00 ± 0.71 4.42 ± 0.27
P12 84.0 126.0 250.0 50.00 ± 0.11 4.39 ± 0.31
P13 84.0 252.0 250.0 37.00 ± 0.41 4.27 ± 0.26
P14 84.0 336.0 250.0 24.00 ± 0.45 4.25 ± 0.35
P15 166.0 166.0 250.0 28.00 ± 0.36 4.31 ± 0.21
P16 42.0 84.0 250.0 55.00 ± 0.43 4.58 ± 0.41
P17 63.2 84.0 250.0 43.00 ± 0.53 4.52 ± 0.32
P18 126.0 84.0 250.0 31.00 ± 0.45 4.40 ± 0.49
P19 168.0 84.0 250.0 54.00 ± 0.32 4.32 ± 0.25
P20 0.0 84.0 250.0 54.00 ± 0.41 4.52 ± 0.27
P21 84.0 0.0 250.0 42.00 ± 0.44 4.75 ± 0.32
P22 168.0 0.0 250. 36.00 ± 0.42 4.49 ± 0.30
P23 126.0 0.0 250.0 58.00 ± 0.18 4.59 ± 0.28
P24 126.0 0.0 125.0 78.00 ± 0.39 4.58 ± 0.41
P25 126.0 0.0 187.5 48.00 ± 0.52 4.54 ± 0.29
P26 126.0 0.0 375.0 55.00 ± 0.22 4.55 ± 0.22
P27 126.0 0.0 500.0 39.00 ± 0.37 4.52 ± 0.31