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. 2019 Sep 14;48:264–276. doi: 10.1016/j.ebiom.2019.09.016

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© 2019 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — GPR4 was overexpressed and predicted a poor prognosis in CRC.

(a) GPR4, GPR68, GPR65 and GPR132 relative mRNA expression levels in colorectal cancer and non-tumour tissues in the GSE20842 dataset. (b) GPR4, GPR68, GPR65 and GPR132 relative mRNA expression levels in colorectal cancer and non-tumour tissues in the TCGA dataset. (c) Kaplan-Meier analyses of the overall survival of the Cancer Genome Atlas (TCGA) cohort patients with high GPR4 expression versus those with low GPR4 expression. (d) GPR4 protein expression in CRC tumour and adjacent non-tumour tissues. (e) Representative examples of CRC tissue array immunostaining for GPR4 in CRC tumour tissues and corresponding non-tumour tissue. Endothelial cells pointed out with black arrow. Scale bars, 500 μm. (f) Statistical analysis of GPR4 staining results for different tumour stages. (g) Kaplan-Meier analyses of the overall survival of patients with colorectal cancer based on GPR4 IHC staining. Differences between the groups in (a, b) were analysed by unpaired Student's t-test (* P < .05; ** P < .01; *** P < .001). Differences between two groups in (c, g) were analysed by log-rank test. (* P < .05; ** P < .01; *** P < .001).