Fig. 6.

The effect of FoxO1 on tubular apoptosis in the kidney of diabetic mice. (A) Representative of TUNEL staining showed apoptotic nuclei (green) in diabetic tubules. Original magnification, 200×. (B) Results of TUNEL analysis were quantified. (C) Representative western blot of Bcl2 and Bax in mice kidneys. (D-E) Quantitative analysis of the densitometry of Bcl2 and Bax. Data were shown as the mean ± SEM, n = 5, *P < .05 vs. the WT mice; #P < .05 vs. the WT-DM mice. P values were determined by one-way ANOVA analysis. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)