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. 2019 Nov 6;104(3):544–558.e6. doi: 10.1016/j.neuron.2019.07.028

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Crown Copyright © 2019 Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Persistence in Odor Tracking Depends on Dopamine Signaling

(A) Scheme of dopaminergic neurons innervating MB lobes.

(B) Running speed of hungry flies at trial 1 and 10 (24 h starved) with inactivated output of either PAM DANs (58E02-Gal4>UAS-Shi^ts1) or TH+/PPL DANs (TH-Gal4>UAS-Shi^ts1).

(C) Average running speed over 10 trials for hungry flies (24 h starved) with inactivated output of PAM DANs (58E02-Gal4>UAS-Shi^ts1) or TH+ DANs (TH-Gal4>UAS-Shi^ts1) compared to control. The boxplot displays the main group effect.

(D) Running speed during trial 1 and 10 of hungry flies (24 h starved) with inactivated output of different subsets of DANs within the TH-Gal4 positive DAN cluster.

(E) Average running speed during odor stimulation over 10 trials of hungry flies (24 h starved) with inactivated output of different DAN/TH+ subsets. The boxplot displays the main group effect.

(F) Table of TH-Gal4 transgenes in different clusters of DANs.

(G) Scheme displaying PPL1-γ1pedc (MP1) DAN innervating the MB.

(H) Running speed during trial 1 and 10 of hungry flies (24 h starved) with inactivated output of PPL1-γ1pedc (MP1) compared to controls.

(I) Average running speed during odor stimulation over 10 trials of hungry flies (24 h starved) with inactivated output of PPL1-γ1pedc (MP1) compared to controls. The boxplot displays the main group effect.

(J) Running speed during trial 1 and 10 of hungry flies (24 h starved) lacking the Dop1R2 receptor gene and heterozygous controls.

(K) Average running speed during odor stimulation over 10 trials of hungry flies (24 h starved) without Dop1R2 compared to heterozygous controls. The boxplot displays the main group effect.

(L) Running speed during trials 1 and 10 for hungry flies (24 h starved) with Dop1R2 receptor knockdown in αβ Kenyon cells (MB008B>Dop1R2i) compared to controls (pBDPU>Dop1R2i).

(M) Average running speeds over 10 trials for hungry flies (24 h starved) with Dop1R2 receptor knockdown in αβ Kenyon cells (MB008B>Dop1R2i) compared to controls (pBDPU>Dop1R2i). The boxplot displays the main group effect.

(N) Model of neurons implicated in persistent odor tracking (see main text for details).

For all analyses, statistical notations are as follows: ns, p > 0.05; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001; ∗∗∗∗, p < 0.0001. In all panels, error bars denote SEM.