Table 1.
Patient details and raw bifurcation counts
| Patient ref |
Disease | Age | Total crypts | CCO+ crypts | CCO− crypts | CCO partial crypts | Total bifurcation events | Type I bifurcation events (% of total) |
Type II bifurcation events (% of total) |
Type III bifurcation events (% of total) |
Fission/fusion rate (per crypt per year) (95% CI) |
Duration of fission/fusion (weeks) (95% CI) |
| 1 | None | 79 | 4919 | 4086 | 497 | 336 | 7 | 5 (71.4%) | 2 (28.6%) | 0 | 0.009 (0.007 to 0.011) | 3.9 (3.1 to 4.7) |
| 2 | None | 60 | 3547 | 3424 | 70 | 53 | 3 | 3 (100%) | 0 | 0 | 0.005 (0.001 to 0.009) | 4.1 (1.3 to 6.8) |
| 3 | None | 64 | 6958 | 6798 | 101 | 59 | 5 | 5 (100%) | 0 | 0 | 0.002 (0.001 to 0.003) | 9.1 (2.5 to 15.7) |
| 4 | FAP | 67 | 6417 | 5910 | 287 | 220 | 44 | 41 (93.2%) | 1 (2.3%) | 2 (4.5%) | 0.017 (0.013 to 0.021) | 10.7 (8.1 to 13.2) |
| 5 | FAP | 59 | 4095 | 3713 | 193 | 189 | 23 | 20 (87.0%) | 3 (13.0%) | 0 | 0.033 (0.024 to 0.042) | 4.4 (3.2 to 5.7) |
| 6 | FAP | 39 | 3085 | 3018 | 43 | 24 | 48 | 48 (100%) | 0 | 0 | 0.010 (0.002 to 0.019) | 40.7 (6.8 to 74.6) |
| 7a | AFAP | 64 | 5448 | 5213 | 148 | 87 | 54 | 50 (92.6%) | 3 (5.6%) | 1 (1.9%) | 0.012 (0.008 to 0.017) | 20.9 (13.3 to 28.6) |
| 7b | AFAP | 64 | 5065 | 4463 | 291 | 311 | 25 | 20 (80.0%) | 3 (12.0%) | 2 (8.0%) | 0.012 (0.008 to 0.015) | 11.0 (8.0 to 14.0) |
| 8 | AFAP | 65 | 11 755 | 11 351 | 213 | 191 | 25 | 18 (72.0%) | 0 | 7 (28.0%) | 0.014 (0.010 to 0.018) | 3.9 (2.8 to 5.1) |
| 9 | AFAP | 61 | 4174 | 3641 | 282 | 251 | 27 | 20 (74.1%) | 2 (7.4%) | 5 (18.5%) | 0.027 (0.021 to 0.034) | 6.2 (4.7 to 7.7) |
| 10 | AFAP | 60 | 2038 | 1962 | 52 | 24 | 16 | 14 (87.5%) | 1 (6.3%) | 1 (6.3%) | 0.011 (0.004 to 0.019) | 17.1 (6.3 to 28.0) |
| 11a | IBD | 66 | 272 | 256 | 15 | 1 | 3 | 3 (100%) | 0 | 0 | ND | ND |
| 11b | IBD | 66 | 402 | 378 | 21 | 3 | 1 | 1 (100%) | 0 | 0 | ND | ND |
| 12 | IBD | 72 | 301 | 238 | 58 | 5 | 3 | 1 (33.3%) | 0 | 2 (66.7%) | ND | ND |
| 13 | IBD | 65 | 1245 | 1057 | 102 | 86 | 25 | 22 (88.0%) | 2 (8.0%) | 1 (4.0%) | ND | ND |
| 14 | None | 42 | 2702 | ND | ND | ND | ND | ND | ND | ND | 0.020 (0.006 to 0.034) | ND |
| 15 | None | 50 | 2878 | ND | ND | ND | ND | ND | ND | ND | 0.009 (0.001 to 0.017) | ND |
| 16 | None | 50 | 2883 | ND | ND | ND | ND | ND | ND | ND | 0.015 (0.006 to 0.024) | ND |
| 17 | None | 62 | 12 030 | ND | ND | ND | ND | ND | ND | ND | 0.007 (0.004 to 0.010) | ND |
| 18 | None | 65 | 29 839 | ND | ND | ND | ND | ND | ND | ND | 0.003 (0.002 to 0.004) | ND |
| 19 | None | 72 | 4101 | ND | ND | ND | ND | ND | ND | ND | 0.005 (0.002 to 0.008) | ND |
| 20 | None | 74 | 8792 | ND | ND | ND | ND | ND | ND | ND | 0.014 (0.011 to 0.017) | ND |
| 21 | None | 74 | 22 045 | ND | ND | ND | ND | ND | ND | ND | 0.012 (0.010 to 0.014) | ND |
| 22 | None | 80 | 6249 | ND | ND | ND | ND | ND | ND | ND | 0.014 (0.010 to 0.018) | ND |
| 23 | None | 82 | 10 341 | ND | ND | ND | ND | ND | ND | ND | 0.016 (0.014 to 0.018) | ND |
| 24 | None | 84 | 11 821 | ND | ND | ND | ND | ND | ND | ND | 0.024 (0.020 to 0.028) | ND |
Patients 1–13 had serial sections available and were used to score crypt bifurcation frequencies.
Patients 14–24 had only a single section available and were used to assess CCO− patch size.
AFAP, attenuated familial adenomatous polyposis; CCO, cytochrome c oxidase; FAP, familial adenomatous polyposis; ND, not detemined.