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. 2019 Nov 8;10:5109. doi: 10.1038/s41467-019-13098-1

Geminal group-directed olefinic C-H functionalization via four- to eight-membered exo-metallocycles

Keke Meng 1, Tingyan Li 1, Chunbing Yu 1, Cong Shen 1, Jian Zhang 1,✉, Guofu Zhong 1,✉
PMCID: PMC6841671  PMID: 31704916

Abstract

Great efforts have been made in the activation of a C(alkenyl)-H bond vicinal to the directing group to proceed via five- or six-membered endo-metallocycles. In stark contrast, functionalization of a C(alkenyl)-H bond geminal to the directing group via exo-metallocycle pathway continued to be elusive. Here we report the selective transformation of an olefinic C-H bond that is geminal to the directing group bearing valuable hydroxyl, carbamate or amide into a C-C bond, which proceeds through four- to eight-membered exo-palladacycles. Compared to the reported mechanisms proceeding only through six-membered exo-palladacycles via N,N-bidentate chelation, our weak and O-monodentate chelation-assisted C(alkenyl)-H activations tolerate longer or shorter distances between the olefinic C-H bonds and the coordinating groups, allowing for the functionalizations of many olefinic C-H bonds in alkenyl alcohols, carbamates and amides. The synthetic applicability has been demonstrated by the preparative scale and late-stage C-H functionalization of steroid and ricinoleate derivatives.

Subject terms: Catalytic mechanisms, Homogeneous catalysis, Synthetic chemistry methodology

Identifying distinct cyclometallation pathways is essential to new types of C-H activation and functionalization in organic synthesis. Here, the authors show the activation of an olefinic C-H bond geminal to the directing group via four- to eight-membered exo-palladacycles with broad substrate scope.

Introduction

Alkenes are commonly present structural motifs and are versatile building blocks in organic synthesis1. Direct functionalization of unactivated alkenyl C-H bonds represents the most straightforward way to valuable alkenes from simpler ones2–8. A fundamental transformation for direct olefinic C-H functionalization is the Heck reaction, which proceeds by olefin insertion followed by β-hydride elimination2–4. In recent years, radical C-H alkenylations have also been developed with a variety of carbon/heteroatom-centered radicals, proceeding through radical addition to alkenes and following single-electron-transfer (SET) oxidation/elimination5. However, the site- and stereo-selectivity of these methods are largely governed by intrinsic steric and electronically biased properties of the alkene substrates due to the addition-elimination mechanisms. Actually, controlling the site- and stereo-selectivity of C(alkenyl)-H cleavage still remains a formidable challenge due to very subtle differences in terms of bond strength and electronic properties.

Pioneered by Murai´s work on Ru-catalyzed carbonyl-directed ortho-C–H activation, broadly defined directing groups (DGs) have served as highly effective tools for controlling C–H bond activations via cyclometallations6–8. Most of the directed aromatic- and aliphatic C-H activations proceeded through a normal five- or six-membered cyclometallated intermediate, however, there are very limited reports on protocols by distinct cyclometallations. The Yu group previously disclosed a Pd(II)-catalyzed aromatic C-H functionalizations directed by distal weakly coordinating functional groups via six- or seven-membered cyclopalladation9. The same group also reported a nitrile-based template directed meta-selective C–H alkenylation, proceeding by a macrocyclic pre-transition state10,11. Functionaliztion of para C–H bonds was addressed as well using the similar template-based strategy by the Maiti group12. Chelation-assisted strategy was also widely used in aliphatic C–H activations13. The Gaunt group reported a palladium-catalyzed C–H bond activation through a four-membered cyclopalladation pathway, leading to the selective synthesis of nitrogen heterocycles14. Sanford and co-workers described a nitrogen-directed transannular C(alkyl)-H activation of alicyclic amine cores15. Very recently, the Yu group disclosed an aliphatic γ-C–H arylation protocol to be proceeded by conventionally disfavored six-membered cyclopalladation, using a strained directing group derived from pyruvic acid16. Considering the number of novel reactions that have arisen from metallacycle intermediates, identification of distinct cyclometallation pathways would lead to novel C–H bond transformations.

Remarkable efforts have been made in the vicinal group-directed olefinic C-H bond functionalization such as alkenylation17–19, alkynylation20–22, alkylation23,24, and others25–34. However, their applicability can be severely curtailed by vicinal selectivity displayed through the only 5- or 6-membered endo-metallocycles, and by the biased electronic and steric properties of the alkene substrates (Fig. 1a). Moreover, the cyclometallation concept has been remarkably expanded to positional selective C-H bond activation in arenes and alkanes6–16, but its utilization in site-selective C(alkenyl)-H bond functionalization still remains elusive17–35.

Fig. 1.

Fig. 1

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Chelation-assisted olefinic C-H functionalization. a, b Type of group-directed olefinic C–H activation. c Reports on geminal olefinic C–H activation by bicyclic palladacycles. d Geminal olefinic C–H functionalization of alkenyl alcohols, carbamates and amides (this work). e Structurally related bioactive and natural molecules

Formation of exo-metallocycle is rare in catalytic reactions36–39 and is often less competitive when forming an endo-metallocycle is possible, presumably due to added conformational degrees of freedom and increased energy (Fig. 1b)41. Dong and co-workers demonstrated an exo-directing-group-enabled functionalization of sp3 C–H bonds via five-membered exo-palladacycles to provide 1,2-diols38. Recently, Engle’s group reported a carboxylic acid-enabled C(alkenyl)-H functionalization via a characterized six-membered palladacycle, using strong N,N-bidentate auxiliary which was removable under nickel-catalyzed methanolysis conditions39. Carreira and co-workers also demonstrated an alkenyl C–H iodination via six-membered alkenyl palladacycle intermediate, using picolinamide as the bidentate-chelation directing group (Fig. 1c)40. However, the major limitation is that the exquisite selectivity is strictly restricted to the cleavage of the C(alkenyl)–H bond that will result in six-membered exo-cyclopalladation. Moreover, the installation and removal of strongly coordinating directing group may impede the widespread application of these transformations.

Hydroxyl, carbamate and amide are valuable and widely occurring functionalities which have been used in C–H functionalizaiton6–8, and we envisioned that these weak and mono-dentate directing group could also enable the distal geminal C(alkenyl)-H activation by mono-cyclic exo-cyclometallation. Comparing to thermodynamically more stable and bicyclic palladacycles by N,N-bidentate chelation, mono-dentate-chelation protocol may functionalize widespread geminal carbon centers that are one or more bonds further away from functional groups, by the formation of small- to medium-sized mono-cyclic metallocycle intermediate, which are transient but less strained. While the formation of four-membered metallocycle is highly challenging, seven- and eight-membered cyclometallation are also much less favored in general as the aliphatic carbon between the alkenyl motif and the coordinating group rotates freely and increases the entropic barrier significantly9,14. In line with our ongoing interest in olefinic C–H activation19,34, herein, we focus on gem-olefinic C-H activation via four- to eight-membered exo-cyclometallation, and the utility is characterized by the C–H functionalization of a wide range of functionalized alkenes, including synthetically valuable homoallyl-, bishomoallyl- and allyl alcohols/carbamates/amides that constitute integral structural motifs in natural products and drug design (Fig. 1d, e).

Results

Development of gem-group-directed alkenyl C-H alkenylation

As the alcohol can be naturally incorporated into the product without installation and removal steps in C–H functionalization, we started investigation by employing previously reported Ru-, Rh- or Pd-catalyzed systems for hydroxyl-chelation-assisted C–H alkenylation reactions42–44. Unfortunately, (E)-3-hexen-1-ol with acrylate led to trace alkenylated/alkylation product and/or poor regioselectivity under a variety of catalytic conditions. In this context, we envisioned that (Z)-alkenyl alcohol could be suitable due to the following two inherent effects. First, incorporation of R1 group would make target olefinic C–H bond more reactive (Fig. 1b) due to increased nucleophilicity toward transition metal and block or obviate competitive vicinal C-H activation sites. Second, absence of R2 group would avoid steric repulsion and facilitate subsequent insertion step. Although various of ligands were inefficient, mono-N-protected amino acid (MPAA) combined with palladium was found to promote the alkenylation reaction45,46, with Ac-Phe-OH emerging as the best one (see Supplementary Table 1). Fine-tuning the chain length between the hydroxyl and olefinic carbon greatly influenced such C-H functionalization. While the reactions of (Z)-3-hexen-1-ol (1a) (5-exo) reacted smoothly with acrylate to provide diene 3 in 69% yield, cis-2-hexen-1-ol (4-exo) and cis-4-decen-1-ol (6-exo) led to desired products in only 30% and 15% yields respectively (Table 1, entries 1–3). However, cis-5-octen-1-ol (7-exo) failed to react (Table 1, entry 4). Reactions of differently substituted alkenyl alcohols were performed to investigate the steric and electronic influences on geminal C-H activation. Unfortunately, (E)-3-hexen-1-ol and 4-methyl-3-penten-1-ol led to trace product due to the difficulty in formation of exo-palladacycle and/or alkenylation by steric repulsion (Table 1, entries 5 and 6). Meanwhile, terminal alkenyl alcohol showed very limited reactivity presumably due to the decreased nucleophilicity of C-H bond toward transition metal (Table 1, entry 7). Carbamate derived from (Z)-allylic alcohol also led to satisfactory results with the help of Ac-Ile-OH ligand instead via 6-membered exo-palladacycle (Table 1, entry 8). However, homoallyl carbamate did not react (7-exo) (Table 1, entry 9). Similarly, other differently substituted alkenyl carbamate exhibited no reactivity toward acrylate due to disfavored steric and/or electronic influences (Table 1, entries 10–12). Although acrylamides were commonly used in alkenyl C-H fucntionalization, there is still no report on Csp2-H transformation of nonconjugated alkenyl amides17–35. Herein, amide was successfully demonstrated to be effective in geminal C-H functionalization. Both secondary and tertiary amides provided corresponding geminal products in good yields, which proceeded by 6-membered palladacycles (Table 1, entries 13 and 14). Notably, this protocol also allowed palladium catalyst to functionalize alkenes bearing longer or shorter chain lengths between the amide and olefinic carbon, which proceeded by 5- and even 7-membered palladacycles, albeit with moderate yields (Table 1, entries 15 and 16). Interestingly, a weak coordinating of amide to form 8-membered palladacycle was also observed, albeit with most of the amide substrate recovered (Table 1, entry 17). Moreover, steric and electronic influences on geminal C-H activation were consistent with the reactions of alcohols and carbamates (Table 1, entries 18–20). All of these results showed a precise recognition of distance and geometry in these alkenyl C-H functionalizations. Other alcohol-derived functional groups (FGs), such as ester (FG5), ether (FG6), urea (FG7), acetone oxime ether (FG8) and amides with acidic N-H bonds (FG9 and FG10), were also tested, but none of them could furnish desired C-H functionalization (Table 1, entries 21–26).

Table 1.

Development of gem-group-directed olefinic C–H alkenylation

graphic file with name 41467_2019_13098_Figa_HTML.gif
entry FG R1 R2 n conditions yield (%)a metallocycleb
1 FG1 Pr H 0 A 30 (3va) 4
2 FG1 Et H 1 A 69 (3aa) 5
3 FG1 pentyl H 2 A 15 (3za) 6
4 FG1 Et H 3 A <5 7
5 FG1 Me Me 1 A <5 5
6 FG1 H Et 1 A 5 5
7 FG1 H H 1 A <5 5
8 FG2 Pr H 0 B 56 (5aa) 6
9 FG2 Et H 1 B <5 7
10 FG2 Me Me 0 B 0 6
11 FG2 H H 0 B 0 6
12 FG2 H Pr 0 B 0 6
13 FG3 pentyl H 1 C 74 (7aa) 6
14 FG4 pentyl H 1 C 60 (7ha) 6
15 FG4 pentyl H 0 C 40 (7qa) 5
16 FG4 Et H 2 C 37 (7ra) 7
17 FG4 Et H 3 C 18 (7ta) 8
18 FG4 Me Me 1 C 0 6
19 FG4 H H 1 C 0 6
20 FG4 H Me 1 C 0 6
21 FG5 Et H 0,1 A,B,C 0 –
22 FG6 Et H 0,1 A,B,C <5 –
23 FG7 Pr H 0,1 A,B,C 0 –
24 FG8 Pr H 0,1 A,B,C 0 –
25 FG9 pentyl H 0,1 A,B,C 0 –
26 FG10 pentyl H 0,1 A,B,C 0 –
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aThe yields are isolated yields

bThe sizes of exo-metallocycles

Substrate scope

With the optimized reaction conditions in hand, we firstly examined the scope and limitation of alkenes 2 by employing alcohol 1a as the substrate (Table 2). It was found that a wide variety of acrylates 2 could provide the alkenylated products in 39–81% yields (3aa-3ai). Remarkably, vinyl ketones were also suitable coupling partners (3aj and 3ak). Moreover, both vinyl phosphonate and styrene were reacted smoothly, affording products 3al and 3am in 75% and 54% yields, respectively. Even acrylamides reacted well, though amides are usually prone to coordination (3an and 3ao). Thereafter, we turned our attention to expand the scope of the reaction to other representative homoallylic alcohols 1. Alcohols bearing longer alkyl chain also reacted well (3ba and 3ca). Introducing of alkyl group at the allylic position showed moderate yield (3da). The versatile catalytic system was not limited to primary alcohols. Indeed, we were pleased to identify easily oxidized secondary alcohols as viable substrates in this protocol likewise47. Incorporation of alkyl, aryl and even alkenyl groups at the carbon adjacent to hydroxyl group showed good results (3ea-3sa). In particular, aryl ring bearing substituents such as F and Cl can be well tolerated in this protocol (3na and 3oa), which is synthetically useful for further elaborations of the products. Unfortunately, alkenyl alcohol bearing sensitive para-Br led to decreased yield due to undesired side reactions (3qa). Interestingly, easily decomposed tertiary alcohol also reacted, but leading to cyclization products 3A (33%) and 3A′ (17%) due to restricted conformational freedom and bond angle compression. Herein, the Z-configuration of product 3A′ implied the involvement of the anti-alkoxypalladation process in the cyclization41,42. Moreover, 4-phenyl-3-buten-1-ol converted well (3ua). Cyclic alcohol such as 2-cyclohexene-1-methanol also reacted, albeit with reduced efficiency (3ta).

Table 2.

Olefinic C–H alkenylation of homoallylic alcoholsa

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Notably, simple allyl alcohols, widely used as allylation reagent48,49, are seldom C-H functionalized due to competitive C–H cleavage sites and easy decomposition under catalytic conditions. Meanwhile, four-membered metallocycle is very rare in catalytic reactions14, whose utilization in olefinic C–H activation has not been reported17–35. To our satisfaction, (Z)-allyl alcohols could be alkenylated in moderate yields, using N-acetyl-L-isoleucine (Ac-Ile-OH) as the ligand (3va-3ya). Moreover, cis-4-decen-1-ol was proved to be reactive, albeit with reduced efficiency (3za). The synthetic flexibility afforded by allyl- and bishomoallyl alcohols greatly expands the range of core structures that can subsequently be accessed.

The carbamate was usually employed as both a DG and an alcohol surrogate in C–H activation. Herein, allylic alcohol masked as its carbamate could be well C–H functionalized with the help of Ac-Gly-OH ligand instead (Table 3). Various acrylates could be served as coupling partners (5aa-5ah). Different dialkyl carbamates were examined to optimize the C–H activation, and installation of bulky isopropyl group led to alkenylated product in 62% yield (5da-5fa). Carbamate derived from secondary alcohol also converted without any decrease in efficiency (5ga). 3-Hydroxyl cyclohexene is a widely occurring skeleton in bioactive molecules and is highly attractive substrate for C–H functionalization (Fig. 1e). To our delight, carbamate masked 3-hydroxyl cyclohexene provided 62–70% yields (5ha and 5ia). Notably, cyclohexene bearing quaternary carbon, which can be found in medical molecules such as galantamine, led to 95% yield (5ja). Finally, this protocol also highlighted tolerance of sensitive benzyl and even cinnamyl moieties, producing products 5ka and 5la in 98% and 63% yields respectively.

Table 3.

Olefinic C–H alkenylation of alkenyl carbamatesa

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a The yields are isolated yields based on carbamate 4.

Next, we focused on substrate scope of alkyl amide directed geminal C(alkenyl)-H fucntionalization by 5- to 8-membered palladacycles (Table 4). The C-H alkenylation proceeded smoothly with various olefinic coupling partners such as acrylates, vinyl ketone and even styrene, providing 43–74% yields (7aa-7ah). Differently N-substituted secondary amides also reacted well with acrylates (7ba-7ea). Although primary amide led to trace product, tertiary amides led to good yields (7ha and 7ia). Incorporation of alkyl and benzyl groups at the carbon adjacent to amide group showed good results (7ja, 7ka and 7la). Differently N-substituted alkenyl amides 6m-6q also led to moderate yields proceeded by 5-membered exo-palladacycles. Notably, although alkenyl 6r exhibited decreased reactivity due to the difficulty in the formation of 7-membered exo-palladacycle, incorporation of methyl group greatly facilitate the C-H alkenylation (7sa, 60% yield). Interestingly, amide 6t bearing longer alkyl chain still showed limited reactivity toward acrylate (7ta).

Table 4.

Olefinic C–H alkenylation of alkenyl amidesa

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a The yields are isolated yields based on amide 6.

Competition experiments and mechanistic considerations

Next, competition experiments were performed for acrylate 2a and alcohols 1 or amides 6 under optimal conditions to rank the relative reactivities, thus demonstrating the preferential formation of the related alkenyl metallocycle intermediates (see Fig. 2 and Supplementary Tables 4-5).

Fig. 2.

Fig. 2

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Competition experiments. a Intermolecular competition experiments using alkenyl alcohols or alkenyl amides to rank the reaction trend under Cond. A or Cond C. b Intramolecular competition experiment using compound 9

On the basis of the data compiled from intermolecular competition experiments, the relative reactivities of alcohols 1a, 1v, 8 and 1z´ were ranked to be 1a > 8 > 1v > 1z´ (Fig. 2a, trend under Cond. A). These results exhibited that alkenyl C-H activation by 5-membered exo-palladacycle (1a) occurred preferentially over 4-membered exo-palladacycle (1v), and the C-H activation by 6-membered exo-palladacycle (1z’) was the most disfavored because the added freely rotating sp3 carbon center significantly increases the entropic barrier for assembling the desired transition state, being consistent with our observation in substrate scoping (Table 2). Notably, vicinal Csp2-H functionalization by 5-membered endo-palladacycle (8) was also efficient under Cond. A. However, formation of 5-exo-metallocycle was found to be more competitive than the formation of 5-endo-metallocycle (1a > 8). An alcohol 9 bearing two alkenyl moieties was synthesized and reacted under Cond. A, and the C-H alkenylation only occurred on Z-alkenyl moiety to provide product 9a (Fig. 2b). Both of the inter- and intra-molecular competition experiments showed the preferential formation of 5-exo-palladacycle over 5-endo-palladacycle, being inconsistent with previous reports38,41. Similarly, while 4-methyl-4-pentenamide exhibited limited reactivity (14% yield) and poor selectivity under conditions C, 7ra was obtained in 37% yield, suggesting the preferential formation of exo-palladacycle. Also, competition studies were performed for acrylate 2a with amide 6h, 6q, 6r or 6t under conditions C, and the relative reactivities of amides were ranked to be 6 h > 6q > 6r > 6t. These results were generally consistent with prior substrate scoping (Table 4) and the kinetically and thermodynamically favored exo-cyclopalladation dominating the geminal Csp2-H activation (Fig. 2a, trend under Cond. C). Notably, both substrates 1z’ and 6h converted by the formation of 6-membered exo-palladacycles, but alkenyl amide 6h reacted efficiently because the carbonyl group reduced conformational degrees of freedom. Moreover, while amide 6r did react via 7-exo-cyclopalladation, homoallyl carbamate did not convert even at elevated temperatures (Table 1, entry 9), exhibiting the great influence of coordinating effect. All of these primary results exhibited that the exo- and endo-cyclometallations were governed by coordination strength and conformation effects on the C-H activation step9,16, and the detailed mechanistic studies will be discussed in a later report. Deuterium incorporation experiments supported the irreversibility of the C-H activation steps, and no Z/E isomerization excluded other possible mechanistic pathway such as π-allylpalladium(II) formation or nucleometalation/β-X elimination39,50. These results combined with kinetic isotope effect (KIE) experiments exhibited that the irreversible C-H bond cleavage step originated the site selectivity, thus possible mechanisms based on exo-palladacycles are proposed (see Supplementary Figs. 1–4)51.

Preparative scale synthesis and coordinating group removal

To establish scalability, the conversion of 1a was run at a gram scale to give 3aa in 71% yield (Fig. 3a). Olefinic C-H alkenylation of 4j at a preparative scale was also successful. The removal of the carbamate in 5ja was readily accomplished by reduction at room temperature to give diol 11 in 73% yield (Fig. 3b). Moreover, geminal C-H olefination of alkenyl amides reacted smoothly at gram-scale, providing 7aa and 7ha in good yields. Notably, amide removal was realized by simple hydrolysis, yielding dienoic acid 12 in good yield (Fig. 3c).

Fig. 3.

Fig. 3

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Gram-scale synthesis and directing group removal. a Gram-scale synthesis of compound 3aa. b Gram-scale synthesis of compound 5ja and carbamate removal. c Gram-scale synthesis of compound 7aa/7ha and amide removal

Late-stage C-H functionalization

To further demonstrate the utility of our methods, we attempted late-stage C–H functionalization of natural and medicinal compounds (Fig. 4). Gratifyingly, these protocols were characterized by high chemoselectivity, highlighting the successful conversion of sensitive geraniol and (+)-dehydroabietylamine as well as the cholesteryl derivatives (3ap, 3aq, 3ar and 5jp). Ricinoleate derivatives were smoothly reacted, delivering the targets in good to excellent yields (10aa-10bl, 59–82% yields) (Fig. 4a). Methyl-1-testosterone is an anabolic steroid derivative to treat male testosterone deficiency. Herein, using steroid-derived carbamate 13a as a representative drug molecule for diversification, three different alkenylation analogs were readily accessed (13aa-13aq, 55–76% yields, Fig. 4b). Given that many therapeutic agents contain alkenyl alcohol moieties, we expect our methodology to provide valuable opportunities for streamlining analog generation and thereby accelerating structure-activity relationship studies in drug discovery. Finally, if an inseparable mixture of Z- and E-alkenyl amides 6h was subjected to Cond. C, Z-alkene reacted smoothly to provide diene 7ha in 75% yield, with the unreacted E-isomer successfully recovered (Fig. 4c).

Fig. 4.

Fig. 4

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Late-stage C–H functionalization of natural and pharmaceutical compounds. a Olefinic C–H modifications including natural products and drug derivatives. b Olefinic C–H alkenylation of methyl 1-testosterone derivative. c Selective conversion of inseparable Z/E alkenyl amides

Discussion

In summary, we have presented a chelation-assisted geminal C(alkenyl)-H functionalization of alkenyl alcohols, carbamates and amides by palladium catalysis. Such olefinic C-H functionalization proceeds via unconventional four- to eight-membered exo-palladacycles and allows the alkenylation of (Z)-configurated and cyclic homoallyl-, bishomoallyl-, and allyl alcohols/carbamates/amides, which are particularly important features of numerous natural products and pharmaceutical agents. The protocols tolerate a wide variety of distances between the olefinic C-H bonds and the coordinating groups, enable the gram-scale preparation and modification of ricinoleate and even steroid derivatives, demonstrating the practicality and versatility. Furthermore, the carbamate and amide auxiliary are smoothly removed under mild reduction or hydrolysis conditions. This work greatly expands the utility of current C(alkenyl)-H activation reactions that are based on five- and six-membered endo-/exo-cyclometallation, and we anticipate that this method will find broad applicability in multifarious synthetic endeavors.

Methods

General procedure for C–H alkenylation of alcohols

An oven-dried vial was charged with Pd(OAc)2 (10 mol%, 0.03 mmol), Ac-Phe-OH (50 mol%, 0.15 mmol), Ag2CO3 (1.5 equiv, 0.45 mmol), Cs2CO3 (30 mol%, 0.09 mmol), CF3CH2OH (10 equiv, 3.0 mmol) and 1,4-dioxane (0.6 mL). Then, alcohol 1 (1.0 equiv, 0.3 mmol) and alkene 2 (2.0 equiv, 0.6 mmol) were added into the solution in sequence. The vial was sealed under argon and heated to 70 °C with stirring for 16–24 h. After cooling down, the mixture was concentrated to give the crude product which was directly applied to a flash column chromatography for separation (EtOAc/petroleum ether mixtures).

General procedure for C-H alkenylation of carbamates

An oven-dried vial was charged with Pd(OAc)2 (10 mol%, 0.02 mmol), Ac-Gly-OH (20 mol%, 0.04 mmol), Ag2CO3 (3.0 equiv, 0.60 mmol) and CF3CH2OH (1.0 mL). Then, carbamate 4 (1.0 equiv, 0.20 mmol) and alkene 2 (2.0 equiv, 0.40 mmol) were added into the solution in sequence. The vial was sealed under argon and heated to 80 °C with stirring for 16–24 h. After cooling down, the mixture was filtered and concentrated to give the crude product which was directly applied to a flash column chromatography for separation (EtOAc/petroleum ether mixtures).

General procedure for C-H alkenylation of amides

An oven-dried vial was charged with Pd(OAc)2 (10 mol%, 0.02 mmol), Ac-phe-OH (50 mol%, 0.1 mmol), Ag2CO3 (1.5 equiv, 0.3 mmol), LiOH (30 mol%, 0.06 mmol), CF3CH2OH (5.0 equiv, 1.0 mmol) and MeCN (1.0 mL). Then, amide 6 (1.0 equiv, 0.20 mmol) and alkene 2 (2.0 equiv, 0.4 mmol) were added into the solution in sequence. The vial was sealed under argon and heated to 70 °C with stirring for 16 h. After cooling down, the mixture was concentrated to give the crude product which was directly applied to a flash column chromatography for separation (EtOAc/Petroleum ether mixtures).

Supplementary information

Supplementary Information (11MB, pdf)

Acknowledgements

We gratefully acknowledged National Natural Science Foundation of China (NSFC) (21502037, 21373073 and 21672048), the Natural Science Foundation of Zhejiang Province (ZJNSF) (LY19B020006), and Hangzhou Normal University for financial support. G.Z. acknowledges a Qianjiang Scholar award from Zhejiang Province, China. J.Z. acknowledges a Xihu Scholar award from Hangzhou City, China.

Author contributions

J.Z. and G.Z. supervised and J.Z. conceived the project. K.M., T.L., C.Y., and C.S. performed all of the experiments, and K.M., T.L., and C.Y. contributed equally. J.Z. prepared this manuscript with the assistance of G.Z., K.M., and T.L. All of the authors participated in data analysis and discussions.

Data availability

The authors declare that all data supporting the findings of this study are available within the article and its Supplementary Information files. All data are also available from the corresponding authors upon reasonable request.

Competing interests

The authors declare no competing interests.

Footnotes

Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work.

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Jian Zhang, Email: zhangjian@hznu.edu.cn.

Guofu Zhong, Email: zgf@hznu.edu.cn.

Supplementary information

Supplementary information is available for this paper at 10.1038/s41467-019-13098-1.

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