Table 2.
Analyte Concentrations Over Time (Endotoxin group, n=61)
| Baseline | 2 hours | 6 hours | Group (endotoxin vs. placebo) x time interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Analyte | Q1 | Median | Q3 | Q1 | Median | Q3 | Q1 | Median | Q3 | F statistic | p value |
| Kynurenine (pmol/μL)* | 3.30 | 3.55 | 3.70 | 3.92 | 4.12 | 4.23 | 3.56 | 3.79 | 3.91 | F(2,182.36)=26.50 | <0.001 |
| Tryptophan (pmol/μL)* | 52.57 | 55.28 | 57.40 | 52.19 | 53.84 | 56.00 | 47.20 | 49.34 | 50.11 | F(2,153.35)=50.70 | <0.001 |
| Kynurenic Acid (pmol/μL)* | 0.228 | 0.244 | 0.266 | 0.235 | 0.257 | 0.277 | 0.250 | 0.278 | 0.311 | F(2,157.62)=12.55 | <0.001 |
| Quinolinic Acid (pmol/μL)* | 1.26 | 1.43 | 1.69 | 1.35 | 1.58 | 1.69 | 1.24 | 1.56 | 1.77 | F(2,170.10)=0.55 | 0.58 |
| IL-6, pg/mL* | 1.03 | 1.71 | 2.69 | 50.41 | 98.78 | 153.55 | 3.46 | 4.97 | 8.0 | F(2,180.78)=226.57 | <0.001 |
| TNF-α, pg/mL* | 5.19 | 6.21 | 7.82 | 82.95 | 136.99 | 201.36 | 14.20 | 19.13 | 27.61 | F(2,211.93)=475.71 | <0.001 |
*
Values were transformed by base 10 logarithm before all statistical analyses, but original scale medians and IQR are presented here.