Table 1.
Pharmacokinetic parameters of 6-deoxy-6-[(5/6)-fluoresceinylthioureido]-(2-hydroxypropyl)-β-cyclodextrin (FITC-HPBCD), administered intravenously to mice.
| Group F | Group NF | Group F | Group NF | ||
|---|---|---|---|---|---|
| Dose (µg) | 250 | 250 | Dose (µg) | 250 | 250 |
| t1/2 (1–15 min) | 7.82 ± 1.48 | 6.13 ± 0.78 | t1/2 (1–15 min) | 7.5 ± 1.13 | 6.50 ± 0.31 |
| t1/2 (15–30 min) | 7.54 ± 0.52 | 35.01 ± 10.15 | t1/2 (15–45 min) | 13.55 ± 1.45 | 13.36 ± 3.05 |
| t1/2 (30–60 min) | 122.3 ± 109.4 | 16.61 ± 7.12 | t1/2 (45–60 min) | 20.06 ± 3.89 | 8.99 ± 4.54 |
| ke (1–15 min) | 0.092 ± 0.023 | 0.115 ± 0.017 | ke (1–15 min) | 0.095 ± 0.017 | 0.107 ± 0.006 |
| ke (15–30 min) | 0.092 ± 0.007 | 0.022 ± 0.009 | ke (15–45 min) | 0.052 ± 0.007 | 0.054 ± 0.013 |
| ke (30–60 min) | 0.022 ± 0.029 | 0.049 ± 0.020 | ke (45–60 min) | 0.036 ± 0.008 | 0.095 ± 0.044 |
| kc (1–15 min) | 0.109 ± 0.026 | nd | kc (1–15 min) | 0.142 ± 0.033 | nd |
| Vd (mL) | 4.86 ± 0.21 | 4.70 ± 1.27 | Vd (mL) | 6.25 ± 0.77 | 7.01 ± 0.81 |
| CL (mL/min) | 0.11 ± 0.15 | 0.25 ± 0.15 | CL (mL/min) | 0.23 ± 0.08 | 0.69 ± 0.38 |
Group F: pharmacokinetic parameters followed the two-compartment, first-order kinetic model. Group NF: pharmacokinetic parameters did not follow the two-compartment, first-order kinetic model. Vd: Volume of distribution at 1 min. CL: clearance. nd: kc values in Group NF could not be determined.