Figure 8.

SDH5 in primary cancer lung cancer is correlated with the expression of PD-L1.

Loss of SDH5 expression correlates with changes in PD-L1 and EMT marker expression in clinical specimens from lung cancer patients. (a). Representative images of the position of CT-guided percutaneous needle biopsy of lung cancer. (b). Expression levels of SDH5, PD-L1, β-catenin, p-GSK-3β (Ser-9) and ZEB1 in normal (n = 3) and lung cancer (n = 3) tissues were determined by Western blot analysis. Densitometry was used to determine relative protein levels, and all proteins were normalized to the levels of β-actin. (c). Elevated mesenchymal markers and PD-L1 in lung cancer tissues. H&E staining was used to identify lung cancer patients’ pathology (magnification, x100).