Table 3.

Cord blood Alpha Klotho according to Placental Characteristics

	N	AK Level pg/ml Median [IQR]	P-Value
Placental weight small for gestational age
No	24	3066 [2180, 3822]	<0.001
Yes	30	1240 [859, 2588]
MVM Status
Any MVM
No	29	2475 [1657, 3510]	<0.05
Yes	25	1230 [805, 3606]
Mild MVM
No	50	2075 [1208, 3410]	NS
Yes	4	4146 [1586, 4686]
Severe MVM
No	33	2654 [1657, 3816]	<0.01
Yes	21	1170 [760, 2645]
MVM sublesion
Vascular Sublesions
Any Vascular
No	29	2475 [1657, 3510]	<0.05
Yes	25	1230 [805, 3606]
Fibrinoid necrosis/acute atherosis
No	43	2370 [1275, 3530]	NS
Yes	11	1050 [600, 3390]
Mural hypertrophy of membrane arterioles
No	44	2415 [1376, 3740]	NS
Yes	10	958 [671, 1766]
Muscularization of basal plate arterioles
No	38	2468 [1575, 3600]	<0.05
Yes	16	1200 [794, 2804]
Decidual vascular thrombosis
No	53	2180 [1226, 3510]	NS
Yes	1	242
Villous Sublesions
Any Villous			<0.05
No	29	2475 [1657, 3510]
Yes	25	1230 [805, 3606]
Villous infarcts
No	44	2338 [1235, 3485]	NS
Yes	10	1070 [657, 3869]
Increased syncytial knots
No	29	2475 [1657, 3510]	<0.05
Yes	25	1230 [805, 3606]
Villous agglutination
No	46	2243 [1245, 3600]	NS
Yes	8	1163 [624, 3353]
Increased intervillous fibrin
No	45	2305 [1263, 3670]	NS
Yes	9	1170 [648, 3315]
Distal villous hypoplasia/small terminal villi
No	31	2475 [1640, 3530]	<0.05
Yes	23	1170 [770, 3390]
Other domains
Acute inflammation
No	38	1862 [1050, 3485]	NS
Yes	16	2338 [1366, 3730]
Chronic inflammation
No	27	1640 [865, 3294]	NS
Yes	27	2460 [1275, 4410]
Fetal vascular pathology
No	38	2243 [1245, 3869]	NS
Yes	16	1385 [784, 2811]

P-values computed using Kruskal-Wallis non-parametric testing compared to the “no” group. MVM=maternal vascular malperfusion