Table 3.
Mutations selected for by exposure to subinhibitory concentrations of carbapenems
| Isolate |
oprD (bp 964, 965) |
oprD (bp 1,244) | algU (bp 529) | algU (bp 258) | lptG (bp 229) |
|---|---|---|---|---|---|
| PA01 | CT | G | C | G | C |
| PA34 | CT | G | C | C | C |
| PA34‐822D | CT | A (stop) | T | G (Q86H) | T (G77C) |
| PA34‐812M | C‐(stop)a | G | T | G (Q86H) | T (G77C) |
Nucleotides in bold indicate non‐silent mutations and corresponding amino acid substitution identified in parentheses. Nucleotide positions relative to parent isolate PA34.
a
Frameshift event brings premature stop codon into frame 66bp downstream of thymine deletion.