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. 2019 Nov 14;8:e50766. doi: 10.7554/eLife.50766

Figure 6. The effect of ELIC mutants on desensitization.

(A) Normalized ELIC WT and mutant current responses to 30 mM cysteamine in 25 mole% POPG liposomes. (B) Graph of ELIC WT and mutant currents 20 s after application of 30 mM cysteamine normalized to peak response in 25 mole% POPG liposomes (n = 3–7, ± SD, **p<0.01, *p<0.05). (C) Same as (B) for weighted tau (time constants) of desensitization.

Figure 6.

Figure 6—figure supplement 1. Channel properties of ELIC WT and mutant responses to cysteamine b giant liposomes of 25 mole% POPG.

Figure 6—figure supplement 1.

(A) Graph of EC50 for peak responses to cysteamine of ELIC WT and mutants (n = 4–7, ± SD, *p<0.05, **p<0.01). (B) Activation time constants (tau) of ELIC WT and mutants in response to 30 mM cysteamine (n = 4–7, ± SD, *p<0.05).