Figure 5.

Non‐obese diabetic (NOD) mice exhibit distinct responses to different cyclic dinucleotide (CDN) isoforms. (a–d). Pre‐diabetic NOD female mice (age 8 weeks) were treated with cdiGMP, cGAMP or vehicle and 3 hr later levels of serum interferon type I (IFN‐I) (a), and tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and CCL4 (b–d) in spleen were determined. Data are representative of five independent experiments (n = 5/group). Statistical significance was evaluated by one‐way analysis of variance, followed by the Bonferroni multiple comparison test; *P < 0·05, **P < 0·01, ***P < 0·001, ****P < 0·0001 NS, not significant. (e) Trace showing part of the STING DNA sequence from NOD mice compared with B6 mice. Polymorphisms are highlighted.