Figure 2.

Dendritic cells (DCs) treated with cobalt (III) protoporphyrin IX (CoPP), dexamethasone (Dexa) and rosiglitazone (Rgz) produce less interleukin‐6 (IL‐6) and IL‐12p70 cytokines. Production of several cytokines after lipopolysaccharide (LPS) stimulation was evaluated after treatment with CoPP, Dexa and Rgz. Supernatants were harvested after 24 hr incubation with 0·5 µg/ml LPS, and cytokine levels were determined by ELISA. Graphs show (a, b) IL‐10, (c, d) IL‐6, (e, f) IL‐12p70 and (g, h) interferon‐γ (IFN‐γ) fold change from non‐stimulated DCs. DCs from MRL‐Fas^lpr mice (a, c, e and g) and NZM2410 mice (b, d, f and h) are shown. Finally, (i) absolute values of cytokines released after LPS stimulation are shown. *P < 0·05, **P < 0·01, ***P < 0·001 by one‐way analysis of variance. Data are shown as mean ± standard error (n = 4).