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. 2019 Sep 26;134(20):1755–1763. doi: 10.1182/blood.2019001757

Table 2.

Conditioning regimens in groups of patients receiving transplants from MUDs and MMRDs

Donors 1 alkylator (Treo/Flu)*, 2 alkylators (Treo/Flu + Mel or Thio) 2 alkylators (Treo/ Flu + Cy) 2 alkylators + G-CSF/plerixafor ATGAM Thymoglobulin Alemtuzumab No serotherapy Rituximab
MUD, n = 75 21 44 2 8 8 62 3 2 56
MMRD, n = 23 4 8 2 9 2 21 0 0 20
n 25 52 4 17 10 83 3 2 76
*

1 alkylator: June 2012 to November 2014; 2 alkylators: from November 2014; 2 alkylators with G-CSF/plerixafor: from May 2016.

Total doses: Flu, fludarabine 150 mg/m2; Treo, treosulfan 42 g/m2 (36 g/m2 in patients younger than 1 year of age); Mel, melphalan 140 mg/m2; Thio, thiotepa 10 mg/kg; Cy, cyclophosphamide 40 to 120 mg/kg; G-CSF, 10 μg/kg/d for 5 days, plerixafor 240 μg/kg/d for 3 days; ATGAM (Pfizer) 90 mg/kg, thymoglobulin (Genzyme Europe B.V.) 5 mg/kg, alemtuzumab 1 mg/kg, rituximab 100-200 mg/m2 on day −1.