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Schematic showing the in situ sprayed bioresponsive fibrin gel containing anti-CD47@CaCO3 NPs within the post-surgery tumor bed. Anti-CD47@CaCO3 encapsulated in fibrin scavenged H+ in the surgical wound site and precisely released anti-CD47 and thereby promoted the polarization of TAMs (M1-like phenotype) as well as the blockade of the 'don't eat me' signal in cancer cells. Adapted with permission from 80, copyright 2019 Nature Publishing Group.
