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. 2019 Oct 22;9(26):8321–8331. doi: 10.7150/thno.35467

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Lineage tracing of Lgr5⁺ HFSCs and their progeny in papilloma and SCC development. Lgr5-Pten^-/--mTmG mice (n=8) and Lgr5-mTmG mice (n=7) received treatment of DMBA/TPA. Lgr5-Pten^-/--mTmG mice developed HF and epidermal hyperplasia, which contained increased amount of mT^-/mG⁺ cells derived from Lgr5⁺ HFSCs. With progression of the disease, mT^-/mG⁺ cells were found in papillomata and in SCC in Lgr5-Pten^-/--mTmG mice, but not in Lgr5-mTmG mice. SCC, squamous cell carcinoma. Scale bars, 100 μm.