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Complement system and acute-phase response protein changes. (A) Heat map of altered complement system and acute-phase response-associated proteins. Several proteins from the classical complement pathway and the common downstream pathway were reduced in the Keratoconus samples. (B) Complement system and acute-phase response-related protein pathway. Proteins highlighted in blue denote decreases in KCN proteomes. (C) Immunostaining of C4BP in donor and KCN corneal sections.
